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• W1994155911 abstract "In the visual cortex, large basket cells form the cellular basis of long-range lateral inhibition. The present paper focuses on combinations of methods with which large basket cells can be studied in the context of extensive neuronal representations. In the first approach, the topographic relationship between large basket axons and known functional representations such as orientation, direction, and ocular dominance is analysed. Functional mapping is carried out using extracellular electrode recordings or optical imaging of intrinsic signals followed by 3-dimensional anatomical reconstruction of biocytin stained large basket cells in the same regions. In the second approach, the contribution of lateral inhibition to orientation and direction selectivity is assessed using the GABA inactivation paradigm and direct inhibitory projections from the inactivation to recording sites are demonstrated with biocytin staining and injections of [3H]nipecotic acid, a radioactive marker for GABAergic cells. The limitation of these approaches is that they can only be used in cortical regions which lie on the surface of the brain." @default.
• W1994155911 created "2016-06-24" @default.
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• W1994155911 date "2000-11-01" @default.
• W1994155911 modified "2023-10-17" @default.
• W1994155911 title "Combined physiological-anatomical approaches to study lateral inhibition" @default.
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• W1994155911 doi "https://doi.org/10.1016/s0165-0270(00)00299-5" @default.
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