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- W1994156920 abstract "Abstract The metabolic and pharmacodynamic interactions of dextro- and levoproxyphene as well as dextro- and levomethorphan were investigated. Both pairs of enantiomers were shown, by the use of two-substrate kinetic studies, to be metabolized by the same microsomal enzyme system. The concept was tested whether drug action could be prolonged by using the pharmacodynamically less active enantiomer as an inhibitor of metabolism of the more active one. When administered together, dextromethorphan both intensified and prolonged the analgesic activity of levomethorphan as measured by the hot-plate assay. However, levopropoxyphene only intensified the analgesic activity of dextropropoxyphene; SKF 525-A, a known inhibitor of drug metabolism, produced only prolongation of the analgesic effect of dextropropoxyphene." @default.
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- W1994156920 date "1974-11-01" @default.
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- W1994156920 title "Metabolic and pharmacodynamic interactions of enantiomers of propoxyphene and methorphan" @default.
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- W1994156920 doi "https://doi.org/10.1016/0024-3205(74)90333-6" @default.
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