Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994161738> ?p ?o ?g. }
- W1994161738 endingPage "38" @default.
- W1994161738 startingPage "29" @default.
- W1994161738 abstract "Summary Mantle cell lymphoma (MCL) is a distinct lymphoma subtype with a particularly poor clinical outcome. The clinical relevance of the morphological characteristics of these tumours remains uncertain. The European MCL Network reviewed 304 cases of MCL to determine the prognostic significance of histopathological characteristics. Cytomorphological subtypes, growth pattern and markers of proliferation (mitotic and Ki‐67 indices) were analysed. In addition to the known cytological subtypes, classical (87·5%), small cell (3·6%), pleomorphic (5·9%) and blastic (2·6%), we identified new pleomorphic subgroups with mixtures of cells ( classical + pleomorphic type ; 1·6%) or transitions ( classical / pleomorphic type ; 1·6%), which, however, did not differ significantly in overall survival time. Exactly 80·5% of cases displayed a diffuse growth pattern, whereas 19·5% of cases had a nodular growth pattern, which was associated with a slightly more favourable prognosis. A high proliferation rate (mitotic or Ki‐67 indices) was associated with shorter overall survival. Cut‐off levels were defined that allowed three subgroups with different proliferation rates to be discriminated, which showed significantly different clinical outcomes ( P < 0·0001). Based on this large clinicopathological study of prospective clinical trials, multivariate analysis confirmed the central prognostic role of cell proliferation and its superiority to all other histomorphological and clinical criteria." @default.
- W1994161738 created "2016-06-24" @default.
- W1994161738 creator A5009323621 @default.
- W1994161738 creator A5009928308 @default.
- W1994161738 creator A5012101254 @default.
- W1994161738 creator A5017652879 @default.
- W1994161738 creator A5021170936 @default.
- W1994161738 creator A5026788516 @default.
- W1994161738 creator A5027607201 @default.
- W1994161738 creator A5028056694 @default.
- W1994161738 creator A5031480761 @default.
- W1994161738 creator A5033935778 @default.
- W1994161738 creator A5035002547 @default.
- W1994161738 creator A5042300762 @default.
- W1994161738 creator A5046049357 @default.
- W1994161738 creator A5057290942 @default.
- W1994161738 creator A5059097260 @default.
- W1994161738 creator A5063241074 @default.
- W1994161738 creator A5073237444 @default.
- W1994161738 creator A5075157221 @default.
- W1994161738 creator A5081539801 @default.
- W1994161738 creator A5086022396 @default.
- W1994161738 creator A5090442302 @default.
- W1994161738 date "2005-09-20" @default.
- W1994161738 modified "2023-10-18" @default.
- W1994161738 title "Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network" @default.
- W1994161738 cites W1009164044 @default.
- W1994161738 cites W148711857 @default.
- W1994161738 cites W1901559524 @default.
- W1994161738 cites W1955394140 @default.
- W1994161738 cites W1963593700 @default.
- W1994161738 cites W1985689512 @default.
- W1994161738 cites W1986713880 @default.
- W1994161738 cites W1993659376 @default.
- W1994161738 cites W2032034804 @default.
- W1994161738 cites W2036242721 @default.
- W1994161738 cites W2041697732 @default.
- W1994161738 cites W2058540612 @default.
- W1994161738 cites W2060908198 @default.
- W1994161738 cites W2065002439 @default.
- W1994161738 cites W2081039752 @default.
- W1994161738 cites W2087242841 @default.
- W1994161738 cites W2096428903 @default.
- W1994161738 cites W2099700439 @default.
- W1994161738 cites W2114261710 @default.
- W1994161738 cites W2122737399 @default.
- W1994161738 cites W2124314287 @default.
- W1994161738 cites W2126486896 @default.
- W1994161738 cites W2128060586 @default.
- W1994161738 cites W2130526793 @default.
- W1994161738 cites W2159376479 @default.
- W1994161738 cites W2162109567 @default.
- W1994161738 cites W2241314352 @default.
- W1994161738 cites W2309937882 @default.
- W1994161738 cites W2319826005 @default.
- W1994161738 cites W2403460116 @default.
- W1994161738 cites W2408275566 @default.
- W1994161738 cites W2413121969 @default.
- W1994161738 cites W3149356036 @default.
- W1994161738 cites W4293203547 @default.
- W1994161738 cites W4322701642 @default.
- W1994161738 doi "https://doi.org/10.1111/j.1365-2141.2005.05716.x" @default.
- W1994161738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16173960" @default.
- W1994161738 hasPublicationYear "2005" @default.
- W1994161738 type Work @default.
- W1994161738 sameAs 1994161738 @default.
- W1994161738 citedByCount "296" @default.
- W1994161738 countsByYear W19941617382012 @default.
- W1994161738 countsByYear W19941617382013 @default.
- W1994161738 countsByYear W19941617382014 @default.
- W1994161738 countsByYear W19941617382015 @default.
- W1994161738 countsByYear W19941617382016 @default.
- W1994161738 countsByYear W19941617382017 @default.
- W1994161738 countsByYear W19941617382018 @default.
- W1994161738 countsByYear W19941617382019 @default.
- W1994161738 countsByYear W19941617382020 @default.
- W1994161738 countsByYear W19941617382021 @default.
- W1994161738 countsByYear W19941617382022 @default.
- W1994161738 countsByYear W19941617382023 @default.
- W1994161738 crossrefType "journal-article" @default.
- W1994161738 hasAuthorship W1994161738A5009323621 @default.
- W1994161738 hasAuthorship W1994161738A5009928308 @default.
- W1994161738 hasAuthorship W1994161738A5012101254 @default.
- W1994161738 hasAuthorship W1994161738A5017652879 @default.
- W1994161738 hasAuthorship W1994161738A5021170936 @default.
- W1994161738 hasAuthorship W1994161738A5026788516 @default.
- W1994161738 hasAuthorship W1994161738A5027607201 @default.
- W1994161738 hasAuthorship W1994161738A5028056694 @default.
- W1994161738 hasAuthorship W1994161738A5031480761 @default.
- W1994161738 hasAuthorship W1994161738A5033935778 @default.
- W1994161738 hasAuthorship W1994161738A5035002547 @default.
- W1994161738 hasAuthorship W1994161738A5042300762 @default.
- W1994161738 hasAuthorship W1994161738A5046049357 @default.
- W1994161738 hasAuthorship W1994161738A5057290942 @default.
- W1994161738 hasAuthorship W1994161738A5059097260 @default.
- W1994161738 hasAuthorship W1994161738A5063241074 @default.
- W1994161738 hasAuthorship W1994161738A5073237444 @default.
- W1994161738 hasAuthorship W1994161738A5075157221 @default.