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• W1994173556 abstract "Abstract Radiopharmaceuticals based on 212 Pb ( t 1/2 =10.6 h) are of interest for use as an in vivo generator of α -particle emitting 212 Bi ( t 1/2 =60.6 min). Sterically stabilized liposomes were evaluated as carriers of 212 Pb/ 212 Bi radionuclides in the reported study. 212 Pb/ 212 Bi-containing vesicles were prepared by ionophore mediated loading of 212 Pb into preformed liposomes. The liposomal uptake of 212 Pb with or without various concentrations of lead carrier was investigated. The retention of 212 Pb and 212 Bi in liposomes incubated in serum was studied. Conditions were found yielding a high and rapid uptake of 212 Pb in liposomes. 90±2% of 212 Pb was incorporated after 30 min. The retention of radionuclides was high, 95% of 212 Pb and 212 Bi were retained in liposomes after incubating for 20 h at 37°C in serum. The results from the present work indicate that an effective retention of 212 Bi after the β - -decay of 212 Pb is achievable. This technology could be the basis of α -emitting radiopharmaceuticals built upon 212 Pb." @default.
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• W1994173556 date "2003-02-01" @default.
• W1994173556 modified "2023-09-26" @default.
• W1994173556 title "Potential<i>in vivo</i>generator for alpha-particle therapy with²¹²Bi: Presentation of a system to minimize escape of daughter nuclide after decay of²¹²Pb to²¹²Bi" @default.
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• W1994173556 doi "https://doi.org/10.1524/ract.91.2.109.19988" @default.
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