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- W1994174554 abstract "Abstract. The concentration of plasma immunoreactive parathyroid hormone ([IPTH]) increased within one minute after the plasma ionized calcium concentration ([Ca++]) had been lowered by phosphate infusions in 8 cows. The decrease in [Ca++] could be accounted for by a rise in nonultrafiltrable calcium. The plasma total calcium concentration ([CaTot]) remained unchanged during the first 4 minutes of the phosphate infusion. Until this time [IPTH] was inversely related to [Ca++] and directly related to plasma phosphorus concentrations, but not to [CaTot]. Peak levels of [IPTH] were attained at 4 minutes, before the nadir of [Ca++] was reached and prior to a significant fall in [CaTot]. The data suggest that initial decreases in ionized but not in total calcium stimulate parathyroid hormone secretion. They provide evidence for a model of parathyroid hormone secretion which includes a small storage pool available for immediate release in response to a lowering of the [Ca++]. Between 4 and 12 minutes [IPTH] remained approximately constant in association with a continued fall in [Ca^], whereas between 13 and 16 minutes (the end of the phosphate infusions) [IPTH] was decreasing in association with still falling [Ca++]. It can be speculated that the synthesis of PTH is insufficient to account for a sustained increase in [IPTH], or that abrupt decreases of [Ca++] inside the parathyroid cells inhibit the secretion coupling mechanisms. Finally after 16 minutes [IPTH] continued decreasing in relation to the rising [Ca++]." @default.
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- W1994174554 date "1973-04-01" @default.
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- W1994174554 title "The Acute Parathyroid Hormone Response to Changes in Ionized Calcium during Phosphate Infusions in the Cow" @default.
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- W1994174554 doi "https://doi.org/10.1111/j.1365-2362.1973.tb00343.x" @default.
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