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- W1994176114 abstract "ABSTRACT Vibrio cholerae is a facultative human pathogen. In its aquatic habitat and as it passes through the digestive tract, V. cholerae must cope with fluctuations in salinity. We analyzed the genome-wide transcriptional profile of V. cholerae grown at different NaCl concentrations and determined that the expression of compatible solute biosynthesis and transporter genes, virulence genes, and genes involved in adhesion and biofilm formation is differentially regulated. We determined that salinity modulates biofilm formation, and this response was mediated through the transcriptional regulators VpsR and VpsT. Additionally, a transcriptional regulator controlling an osmolarity adaptation response was identified. This regulator, OscR ( os molarity c ontrolled r egulator), was found to modulate the transcription of genes involved in biofilm matrix production and motility in a salinity-dependent manner. oscR mutants were less motile and exhibited enhanced biofilm formation only under low-salt conditions." @default.
- W1994176114 created "2016-06-24" @default.
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- W1994176114 date "2009-07-01" @default.
- W1994176114 modified "2023-09-27" @default.
- W1994176114 title "Identification and Characterization of OscR, a Transcriptional Regulator Involved in Osmolarity Adaptation in <i>Vibrio cholerae</i>" @default.
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- W1994176114 doi "https://doi.org/10.1128/jb.01540-08" @default.
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