FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994176470> ?p ?o ?g. }

• W1994176470 endingPage "738" @default.
• W1994176470 startingPage "732" @default.
• W1994176470 abstract "This study was conducted to evaluate the effects of ghrelin on insulin’s capacity to suppress endogenous glucose production and promote glucose disposal in mice. To establish whether the growth hormone secretagogue (GHS) receptor can mediate the putative effect of ghrelin on the action of insulin, we also determined the metabolic effects of growth hormone releasing peptide 6 (GHRP-6), a specific GHS receptor agonist. In addition, we explored the biological significance of des-ghrelin (unacylated ghrelin) in this experimental context. Vehicle (n=8), ghrelin (n=9), GHRP-6 (n=9), des-ghrelin (n=8) or a combination of des-ghrelin and ghrelin (n=7) were infused i.v. for 3 h. Simultaneously, endogenous glucose production and glucose disposal were measured by 14C-glucose dilution during a hyperinsulinaemic–euglycaemic clamp. Tissue-specific glucose uptake in muscle and adipose tissue was measured using 3H-2-deoxyglucose. During hyperinsulinaemia, glucose disposal was 31% higher in mice treated with ghrelin than in those treated with vehicle (77±16 and 59±8 μmol kg−1 h−1, respectively, p<0.05). This was in accordance with enhanced 2-deoxyglucose uptake in muscle in ghrelin-treated animals. In contrast, endogenous glucose production was less effectively suppressed by insulin during ghrelin infusion (46±22 vs 71±11% in controls, p<0.05). GHRP-6 did not affect insulin action. Des-ghrelin hampered insulin’s capacity to inhibit endogenous glucose production, whereas it did not affect glucose disposal. The restraining effects of des-ghrelin and ghrelin on hepatic insulin action were abolished by simultaneous administration of both peptides. Ghrelin hampers insulin’s capacity to suppress endogenous glucose production, whereas it reinforces the action of insulin on glucose disposal, independently of food intake and body weight. These metabolic effects are unlikely to be mediated by the GHS receptor. Furthermore, simultaneous administration of des-ghrelin abolishes the inhibitory effect of ghrelin on hepatic insulin action." @default.
• W1994176470 created "2016-06-24" @default.
• W1994176470 creator A5019829980 @default.
• W1994176470 creator A5025131217 @default.
• W1994176470 creator A5042579611 @default.
• W1994176470 creator A5071525728 @default.
• W1994176470 creator A5083432581 @default.
• W1994176470 creator A5087117156 @default.
• W1994176470 creator A5090831614 @default.
• W1994176470 date "2006-02-17" @default.
• W1994176470 modified "2023-10-18" @default.
• W1994176470 title "Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice" @default.
• W1994176470 cites W1616806865 @default.
• W1994176470 cites W1637971961 @default.
• W1994176470 cites W1973955359 @default.
• W1994176470 cites W1989130418 @default.
• W1994176470 cites W1994667169 @default.
• W1994176470 cites W1995734405 @default.
• W1994176470 cites W1996421489 @default.
• W1994176470 cites W2021076160 @default.
• W1994176470 cites W2032225465 @default.
• W1994176470 cites W2051197176 @default.
• W1994176470 cites W2051753034 @default.
• W1994176470 cites W2051795474 @default.
• W1994176470 cites W2053680491 @default.
• W1994176470 cites W2055330140 @default.
• W1994176470 cites W2069204226 @default.
• W1994176470 cites W2069302715 @default.
• W1994176470 cites W2072911841 @default.
• W1994176470 cites W2077982572 @default.
• W1994176470 cites W2078991200 @default.
• W1994176470 cites W2097505907 @default.
• W1994176470 cites W2103817177 @default.
• W1994176470 cites W2104301859 @default.
• W1994176470 cites W2105573142 @default.
• W1994176470 cites W2111536564 @default.
• W1994176470 cites W2112202133 @default.
• W1994176470 cites W2112743857 @default.
• W1994176470 cites W2116775721 @default.
• W1994176470 cites W2119580431 @default.
• W1994176470 cites W2132748505 @default.
• W1994176470 cites W2144575734 @default.
• W1994176470 cites W2151773967 @default.
• W1994176470 cites W2160612294 @default.
• W1994176470 cites W2161940036 @default.
• W1994176470 cites W2162102234 @default.
• W1994176470 cites W2163419120 @default.
• W1994176470 cites W2163865122 @default.
• W1994176470 cites W2165641271 @default.
• W1994176470 cites W2165670397 @default.
• W1994176470 cites W2169814087 @default.
• W1994176470 cites W2322773612 @default.
• W1994176470 doi "https://doi.org/10.1007/s00125-006-0138-2" @default.
• W1994176470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16485139" @default.
• W1994176470 hasPublicationYear "2006" @default.
• W1994176470 type Work @default.
• W1994176470 sameAs 1994176470 @default.
• W1994176470 citedByCount "75" @default.
• W1994176470 countsByYear W19941764702012 @default.
• W1994176470 countsByYear W19941764702013 @default.
• W1994176470 countsByYear W19941764702014 @default.
• W1994176470 countsByYear W19941764702015 @default.
• W1994176470 countsByYear W19941764702016 @default.
• W1994176470 countsByYear W19941764702018 @default.
• W1994176470 countsByYear W19941764702019 @default.
• W1994176470 countsByYear W19941764702021 @default.
• W1994176470 countsByYear W19941764702022 @default.
• W1994176470 crossrefType "journal-article" @default.
• W1994176470 hasAuthorship W1994176470A5019829980 @default.
• W1994176470 hasAuthorship W1994176470A5025131217 @default.
• W1994176470 hasAuthorship W1994176470A5042579611 @default.
• W1994176470 hasAuthorship W1994176470A5071525728 @default.
• W1994176470 hasAuthorship W1994176470A5083432581 @default.
• W1994176470 hasAuthorship W1994176470A5087117156 @default.
• W1994176470 hasAuthorship W1994176470A5090831614 @default.
• W1994176470 hasBestOaLocation W19941764701 @default.
• W1994176470 hasConcept C126322002 @default.
• W1994176470 hasConcept C134018914 @default.
• W1994176470 hasConcept C16613235 @default.
• W1994176470 hasConcept C170493617 @default.
• W1994176470 hasConcept C171089720 @default.
• W1994176470 hasConcept C185592680 @default.
• W1994176470 hasConcept C2777391703 @default.
• W1994176470 hasConcept C2777866211 @default.
• W1994176470 hasConcept C2778808658 @default.
• W1994176470 hasConcept C2779168441 @default.
• W1994176470 hasConcept C2779306644 @default.
• W1994176470 hasConcept C2779357093 @default.
• W1994176470 hasConcept C2780161494 @default.
• W1994176470 hasConcept C2780352109 @default.
• W1994176470 hasConcept C71315377 @default.
• W1994176470 hasConcept C71924100 @default.
• W1994176470 hasConcept C86803240 @default.
• W1994176470 hasConceptScore W1994176470C126322002 @default.
• W1994176470 hasConceptScore W1994176470C134018914 @default.
• W1994176470 hasConceptScore W1994176470C16613235 @default.
• W1994176470 hasConceptScore W1994176470C170493617 @default.
• W1994176470 hasConceptScore W1994176470C171089720 @default.

• next