FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994178395> ?p ?o ?g. }

• W1994178395 endingPage "1080" @default.
• W1994178395 startingPage "1070" @default.
• W1994178395 abstract "With the notable exception of B-cell malignancies, the efficacy of chimeric antigen receptor (CAR) T cells has been limited, and CAR T cells have not been shown to expand and persist in patients with nonlymphoid tumors. Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence. Compared with CARs containing the CD3ζ chain alone, or in tandem with the CD28 or the 4-1BB intracellular domains, ICOS signaling increased IL-17A, IL-17F, and IL-22 following antigen recognition. In addition, T cells redirected with an ICOS-based CAR maintained a core molecular signature characteristic of TH17 cells and expressed higher levels of RORC, CD161, IL1R-1, and NCS1. Of note, ICOS signaling also induced the expression of IFN-γ and T-bet, consistent with a TH17/TH1 bipolarization. When transferred into mice with established tumors, TH17 cells that were redirected with ICOS-based CARs mediated efficient antitumor responses and showed enhanced persistence compared with CD28- or 4-1BB-based CAR T cells. Thus, redirection of TH17 cells with a CAR encoding the ICOS intracellular domain is a promising approach to augment the function and persistence of CAR T cells in hematologic malignancies." @default.
• W1994178395 created "2016-06-24" @default.
• W1994178395 creator A5008171524 @default.
• W1994178395 creator A5008558372 @default.
• W1994178395 creator A5020001580 @default.
• W1994178395 creator A5022023053 @default.
• W1994178395 creator A5031401366 @default.
• W1994178395 creator A5044776929 @default.
• W1994178395 creator A5055203249 @default.
• W1994178395 creator A5059501045 @default.
• W1994178395 creator A5064556004 @default.
• W1994178395 creator A5065547362 @default.
• W1994178395 creator A5081974926 @default.
• W1994178395 creator A5091533549 @default.
• W1994178395 date "2014-08-14" @default.
• W1994178395 modified "2023-10-14" @default.
• W1994178395 title "ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells" @default.
• W1994178395 cites W1598217555 @default.
• W1994178395 cites W1761214387 @default.
• W1994178395 cites W1963522404 @default.
• W1994178395 cites W1976162569 @default.
• W1994178395 cites W1981291019 @default.
• W1994178395 cites W1987628377 @default.
• W1994178395 cites W1995391551 @default.
• W1994178395 cites W1997025161 @default.
• W1994178395 cites W2005623930 @default.
• W1994178395 cites W2006428939 @default.
• W1994178395 cites W2021340905 @default.
• W1994178395 cites W2024490058 @default.
• W1994178395 cites W2028417270 @default.
• W1994178395 cites W2029855686 @default.
• W1994178395 cites W2045339312 @default.
• W1994178395 cites W2064272625 @default.
• W1994178395 cites W2070669774 @default.
• W1994178395 cites W2070769098 @default.
• W1994178395 cites W2081052715 @default.
• W1994178395 cites W2087055812 @default.
• W1994178395 cites W2098749176 @default.
• W1994178395 cites W2105400883 @default.
• W1994178395 cites W2107235439 @default.
• W1994178395 cites W2107806760 @default.
• W1994178395 cites W2124513722 @default.
• W1994178395 cites W2130011407 @default.
• W1994178395 cites W2130338247 @default.
• W1994178395 cites W2131678280 @default.
• W1994178395 cites W2131874142 @default.
• W1994178395 cites W2136100686 @default.
• W1994178395 cites W2142616877 @default.
• W1994178395 cites W2144796561 @default.
• W1994178395 cites W2144995154 @default.
• W1994178395 cites W2147172932 @default.
• W1994178395 cites W2151157466 @default.
• W1994178395 cites W2155101465 @default.
• W1994178395 cites W2157041114 @default.
• W1994178395 cites W2167010530 @default.
• W1994178395 cites W2167550136 @default.
• W1994178395 cites W2167926335 @default.
• W1994178395 doi "https://doi.org/10.1182/blood-2013-10-535245" @default.
• W1994178395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4133482" @default.
• W1994178395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24986688" @default.
• W1994178395 hasPublicationYear "2014" @default.
• W1994178395 type Work @default.
• W1994178395 sameAs 1994178395 @default.
• W1994178395 citedByCount "254" @default.
• W1994178395 countsByYear W19941783952014 @default.
• W1994178395 countsByYear W19941783952015 @default.
• W1994178395 countsByYear W19941783952016 @default.
• W1994178395 countsByYear W19941783952017 @default.
• W1994178395 countsByYear W19941783952018 @default.
• W1994178395 countsByYear W19941783952019 @default.
• W1994178395 countsByYear W19941783952020 @default.
• W1994178395 countsByYear W19941783952021 @default.
• W1994178395 countsByYear W19941783952022 @default.
• W1994178395 countsByYear W19941783952023 @default.
• W1994178395 crossrefType "journal-article" @default.
• W1994178395 hasAuthorship W1994178395A5008171524 @default.
• W1994178395 hasAuthorship W1994178395A5008558372 @default.
• W1994178395 hasAuthorship W1994178395A5020001580 @default.
• W1994178395 hasAuthorship W1994178395A5022023053 @default.
• W1994178395 hasAuthorship W1994178395A5031401366 @default.
• W1994178395 hasAuthorship W1994178395A5044776929 @default.
• W1994178395 hasAuthorship W1994178395A5055203249 @default.
• W1994178395 hasAuthorship W1994178395A5059501045 @default.
• W1994178395 hasAuthorship W1994178395A5064556004 @default.
• W1994178395 hasAuthorship W1994178395A5065547362 @default.
• W1994178395 hasAuthorship W1994178395A5081974926 @default.
• W1994178395 hasAuthorship W1994178395A5091533549 @default.
• W1994178395 hasBestOaLocation W19941783951 @default.
• W1994178395 hasConcept C147483822 @default.
• W1994178395 hasConcept C148125776 @default.
• W1994178395 hasConcept C167672396 @default.
• W1994178395 hasConcept C185592680 @default.
• W1994178395 hasConcept C203014093 @default.
• W1994178395 hasConcept C2776090121 @default.
• W1994178395 hasConcept C2779727006 @default.
• W1994178395 hasConcept C3875195 @default.
• W1994178395 hasConcept C502942594 @default.
• W1994178395 hasConcept C74737994 @default.

• next