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• W1994179111 abstract "Abstract Micro RNA s (mi RNA s) have been identified as important post‐transcriptional regulators involved in various biological and pathological processes of cells. In the present study, we investigated the roles and mechanisms of miR‐200b in human breast cancer ( BC ). MiR‐200b expression was carried out by qRT ‐ PCR in human BC cell lines and clinical samples and the prognostic potential of miR‐200b expression was further evaluated. In vitro , effects of miR‐200b on BC cell proliferation, apoptosis and cell cycle distribution were tested by CCK ‐8 kit, flow cytometric analysis respectively. Luciferase assay and Western blot analysis were performed to validate the potential targets of miR‐200b after the preliminary screening by employing open access software. We found that miR‐200b was significantly down‐regulated in both BC tissues and cell lines. The low expression of miR‐200b was correlated with late TNM stage, negative oestrogen receptor and positive HER ‐2 status. Multivariate analysis showed that miR‐200b expression was an independent prognostic predictor for BC patients. Integrated analysis identified Sp1 as a direct and functional target of miR‐200b. Knockdown of Sp1 inhibited cell proliferation, induce apoptosis and act on cell cycle resembling that of miR‐200b high expression. Our data demonstrates that miR‐200b has potential to serve as prognostic biomarker and tumour suppressor for BC patients. As a direct and functional target of miR‐200b, Sp1 and miR‐200b both could be an exciting target for BC treatment strategy." @default.
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• W1994179111 date "2015-01-30" @default.
• W1994179111 modified "2023-10-06" @default.
• W1994179111 title "MiR‐200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting Sp1" @default.
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• W1994179111 doi "https://doi.org/10.1111/jcmm.12432" @default.
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