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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994185989> ?p ?o ?g. }

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• W1994185989 abstract "Significance NMDA receptors (NMDARs) are key components of excitatory synapses. Here we report that Wnt signaling via activation of tyrosine kinase-like orphan receptor 2 can regulate synaptic NMDARs. Understanding what controls number and subunit composition is central to understand neuropathologies associated with dysfunction of synaptic NMDARs, including Alzheimer’s disease and schizophrenia. Our data indicate a previously unidentified role for Wnt signaling in the regulation of established synaptic connections and provides a mechanism for Wnt ligands to modulate basal synaptic transmission, synaptic plasticity, and brain functions acutely." @default.
• W1994185989 created "2016-06-24" @default.
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• W1994185989 date "2015-03-30" @default.
• W1994185989 modified "2023-10-02" @default.
• W1994185989 title "RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission" @default.
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• W1994185989 doi "https://doi.org/10.1073/pnas.1417053112" @default.
• W1994185989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4403196" @default.
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