Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994188051> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W1994188051 abstract "Abstract Conventional analgesics such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are effective in acute pain, but chronic pain is often poorly controlled. This article examines other mechanisms by which pain can be modulated and indicates areas in which pain research is continuing and which new drugs are at the basic research or clinical trial stage. Important candidates include agonists at nicotinic receptors to acetylcholine and the calcium antagonist conotoxins, derived from the sea snail. In some areas, useful improvements to current drug efficacy can be achieved by combination with new agents, such as morphine with cholecystokinin antagonists, or morphine with NMDA antagonists such as dextromethorphan. Some neurotransmitters (e.g. 5-hydroxtryptamine) may induce pain at one receptor but reduce it at another. Achieving analgesia in these circumstances relies on high receptor selectivity or local administration." @default.
- W1994188051 created "2016-06-24" @default.
- W1994188051 creator A5062829083 @default.
- W1994188051 date "2005-02-01" @default.
- W1994188051 modified "2023-10-14" @default.
- W1994188051 title "Other targets for analgesic drugs" @default.
- W1994188051 cites W1966515810 @default.
- W1994188051 cites W1995100344 @default.
- W1994188051 cites W2032050844 @default.
- W1994188051 cites W2102164371 @default.
- W1994188051 cites W2118283115 @default.
- W1994188051 doi "https://doi.org/10.1383/anes.6.2.68.59097" @default.
- W1994188051 hasPublicationYear "2005" @default.
- W1994188051 type Work @default.
- W1994188051 sameAs 1994188051 @default.
- W1994188051 citedByCount "0" @default.
- W1994188051 crossrefType "journal-article" @default.
- W1994188051 hasAuthorship W1994188051A5062829083 @default.
- W1994188051 hasConcept C118552586 @default.
- W1994188051 hasConcept C126322002 @default.
- W1994188051 hasConcept C170493617 @default.
- W1994188051 hasConcept C2777389121 @default.
- W1994188051 hasConcept C2777593968 @default.
- W1994188051 hasConcept C2780035454 @default.
- W1994188051 hasConcept C2780820201 @default.
- W1994188051 hasConcept C2781118164 @default.
- W1994188051 hasConcept C2781245242 @default.
- W1994188051 hasConcept C42219234 @default.
- W1994188051 hasConcept C71924100 @default.
- W1994188051 hasConcept C98274493 @default.
- W1994188051 hasConceptScore W1994188051C118552586 @default.
- W1994188051 hasConceptScore W1994188051C126322002 @default.
- W1994188051 hasConceptScore W1994188051C170493617 @default.
- W1994188051 hasConceptScore W1994188051C2777389121 @default.
- W1994188051 hasConceptScore W1994188051C2777593968 @default.
- W1994188051 hasConceptScore W1994188051C2780035454 @default.
- W1994188051 hasConceptScore W1994188051C2780820201 @default.
- W1994188051 hasConceptScore W1994188051C2781118164 @default.
- W1994188051 hasConceptScore W1994188051C2781245242 @default.
- W1994188051 hasConceptScore W1994188051C42219234 @default.
- W1994188051 hasConceptScore W1994188051C71924100 @default.
- W1994188051 hasConceptScore W1994188051C98274493 @default.
- W1994188051 hasLocation W19941880511 @default.
- W1994188051 hasOpenAccess W1994188051 @default.
- W1994188051 hasPrimaryLocation W19941880511 @default.
- W1994188051 hasRelatedWork W1486790737 @default.
- W1994188051 hasRelatedWork W2019086812 @default.
- W1994188051 hasRelatedWork W2137493657 @default.
- W1994188051 hasRelatedWork W2317873151 @default.
- W1994188051 hasRelatedWork W2417371985 @default.
- W1994188051 hasRelatedWork W2460986560 @default.
- W1994188051 hasRelatedWork W2896741733 @default.
- W1994188051 hasRelatedWork W2899084033 @default.
- W1994188051 hasRelatedWork W2909866125 @default.
- W1994188051 hasRelatedWork W2917524362 @default.
- W1994188051 isParatext "false" @default.
- W1994188051 isRetracted "false" @default.
- W1994188051 magId "1994188051" @default.
- W1994188051 workType "article" @default.