Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994194230> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1994194230 endingPage "329" @default.
- W1994194230 startingPage "319" @default.
- W1994194230 abstract "Inhibitor formation is a serious complication, occurring in 24–52% of patients with haemophilia A and in 1.5–3% of patients with haemophilia B. Low-titre inhibitors can easily be overcome and do not represent a treatment challenge. They are treated with increased doses of factor concentrate. However, high-titre inhibitors may still cause death from haemorrhage in this population. Optimal treatment of acute, life-threatening haemorrhage in patients with factor VIII inhibitors includes either porcine factor VIII or human factor VIII in high doses since, with both modalities, circulating factor levels are achievable. If the inhibitor titres are too high, plasmapheresis may be warranted, for routine joint bleeds, PCC or aPCC can be administered at home with variable success. For patients with factor IX inhibitors treatment options are more limited. If the haemorrhage is life-threatening, plasmapheresis should be done to decrease the inhibitor and high doses of pure factor IX administered either by continuous infusion or bolus. Attainment of levels of > 20% should be attempted. New clinical options, such as rFVIIa, may emerge. For both groups of patients, IT should be started as soon as the inhibitor is discovered and its behaviour characterized. Unfortunately, no standard regimen for IT exists and the treater will have to choose whichever schedule he/she feels is the most appropriate." @default.
- W1994194230 created "2016-06-24" @default.
- W1994194230 creator A5006637113 @default.
- W1994194230 date "1996-06-01" @default.
- W1994194230 modified "2023-09-30" @default.
- W1994194230 title "8 Inhibitors in congenital haemophilia" @default.
- W1994194230 cites W100309492 @default.
- W1994194230 cites W1608541477 @default.
- W1994194230 cites W1700997260 @default.
- W1994194230 cites W1730534368 @default.
- W1994194230 cites W1870852515 @default.
- W1994194230 cites W1969574200 @default.
- W1994194230 cites W1983707924 @default.
- W1994194230 cites W1986231464 @default.
- W1994194230 cites W1992829986 @default.
- W1994194230 cites W1993253824 @default.
- W1994194230 cites W2017164294 @default.
- W1994194230 cites W2021047792 @default.
- W1994194230 cites W2028148688 @default.
- W1994194230 cites W2039466802 @default.
- W1994194230 cites W2042508808 @default.
- W1994194230 cites W2050510640 @default.
- W1994194230 cites W2056634959 @default.
- W1994194230 cites W2081786896 @default.
- W1994194230 cites W2088684447 @default.
- W1994194230 cites W2128406610 @default.
- W1994194230 cites W2139378749 @default.
- W1994194230 cites W226534966 @default.
- W1994194230 cites W2321411638 @default.
- W1994194230 cites W2337290468 @default.
- W1994194230 cites W2337912069 @default.
- W1994194230 cites W2403444710 @default.
- W1994194230 cites W2413894884 @default.
- W1994194230 cites W2417605240 @default.
- W1994194230 cites W2422227088 @default.
- W1994194230 cites W2461702052 @default.
- W1994194230 cites W263306092 @default.
- W1994194230 cites W2734698134 @default.
- W1994194230 doi "https://doi.org/10.1016/s0950-3536(96)80066-7" @default.
- W1994194230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8800508" @default.
- W1994194230 hasPublicationYear "1996" @default.
- W1994194230 type Work @default.
- W1994194230 sameAs 1994194230 @default.
- W1994194230 citedByCount "41" @default.
- W1994194230 countsByYear W19941942302013 @default.
- W1994194230 countsByYear W19941942302016 @default.
- W1994194230 countsByYear W19941942302017 @default.
- W1994194230 countsByYear W19941942302018 @default.
- W1994194230 crossrefType "journal-article" @default.
- W1994194230 hasAuthorship W1994194230A5006637113 @default.
- W1994194230 hasConcept C126322002 @default.
- W1994194230 hasConcept C141071460 @default.
- W1994194230 hasConcept C159654299 @default.
- W1994194230 hasConcept C203014093 @default.
- W1994194230 hasConcept C2777232031 @default.
- W1994194230 hasConcept C2778385053 @default.
- W1994194230 hasConcept C2778842783 @default.
- W1994194230 hasConcept C2778961111 @default.
- W1994194230 hasConcept C2781413609 @default.
- W1994194230 hasConcept C2908647359 @default.
- W1994194230 hasConcept C43376680 @default.
- W1994194230 hasConcept C71924100 @default.
- W1994194230 hasConcept C99454951 @default.
- W1994194230 hasConceptScore W1994194230C126322002 @default.
- W1994194230 hasConceptScore W1994194230C141071460 @default.
- W1994194230 hasConceptScore W1994194230C159654299 @default.
- W1994194230 hasConceptScore W1994194230C203014093 @default.
- W1994194230 hasConceptScore W1994194230C2777232031 @default.
- W1994194230 hasConceptScore W1994194230C2778385053 @default.
- W1994194230 hasConceptScore W1994194230C2778842783 @default.
- W1994194230 hasConceptScore W1994194230C2778961111 @default.
- W1994194230 hasConceptScore W1994194230C2781413609 @default.
- W1994194230 hasConceptScore W1994194230C2908647359 @default.
- W1994194230 hasConceptScore W1994194230C43376680 @default.
- W1994194230 hasConceptScore W1994194230C71924100 @default.
- W1994194230 hasConceptScore W1994194230C99454951 @default.
- W1994194230 hasIssue "2" @default.
- W1994194230 hasLocation W19941942301 @default.
- W1994194230 hasLocation W19941942302 @default.
- W1994194230 hasOpenAccess W1994194230 @default.
- W1994194230 hasPrimaryLocation W19941942301 @default.
- W1994194230 hasRelatedWork W1950105691 @default.
- W1994194230 hasRelatedWork W1966293352 @default.
- W1994194230 hasRelatedWork W1975748178 @default.
- W1994194230 hasRelatedWork W2036182377 @default.
- W1994194230 hasRelatedWork W2073584790 @default.
- W1994194230 hasRelatedWork W2106659439 @default.
- W1994194230 hasRelatedWork W2113430786 @default.
- W1994194230 hasRelatedWork W2117673436 @default.
- W1994194230 hasRelatedWork W2158441938 @default.
- W1994194230 hasRelatedWork W4321429161 @default.
- W1994194230 hasVolume "9" @default.
- W1994194230 isParatext "false" @default.
- W1994194230 isRetracted "false" @default.
- W1994194230 magId "1994194230" @default.
- W1994194230 workType "article" @default.