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• W1994194419 endingPage "9693" @default.
• W1994194419 startingPage "9689" @default.
• W1994194419 abstract "T cells are activated physiologically by triggering the T-cell receptor-CD3 complex. There is evidence that invariant accessory molecules on the T-cell membrane (CD8 and CD4) are involved in the major histocompatibility complex-restricted recognition process. Moreover, binding and crosslinking of these accessory molecules to the T-cell receptor-CD3 complex exerts a positive synergistic signal, as has been shown by stimulation with crosslinked antibodies. Here we demonstrate that stimulation mediated by immobilized anti-CD3/CD8 antibodies differs from stimulation mediated solely by anti-CD3. Whereas interleukin 2 receptor expression and interferon gamma production are seen to a similar extent in both cases, a second signal provided by the additional involvement of CD8 seems to be essential for interleukin 2 production and full interleukin 2 responsiveness in CD8+ T cells. This second signal is much more sensitive to inhibition by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C and cGMP/cAMP-dependent kinases. Our results also show that substantial modulation of the T-cell receptor complex and most likely CD3 phosphorylation are not essential for initiating the activation of resting T cells. Instead, we found a 22- to 24-kDa phosphoprotein whose strong phosphorylation correlated reliably with T-cell activation." @default.
• W1994194419 created "2016-06-24" @default.
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• W1994194419 creator A5067034637 @default.
• W1994194419 date "1988-12-01" @default.
• W1994194419 modified "2023-10-01" @default.
• W1994194419 title "Activation of human T lymphocytes: differential effects of CD3- and CD8-mediated signals." @default.
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• W1994194419 doi "https://doi.org/10.1073/pnas.85.24.9689" @default.
• W1994194419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/282839" @default.
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