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- W1994201515 abstract "In anaesthetized cats methysergide was administered while measuring tonically present supraspinal inhibition of excitation of lumbar dorsal horn neurones by cutaneous noxious stimuli or by impulses in unmyelinated primary afferents. In some experiments inhibition was produced by electrical stimulation near the medullary raphe. Administered electrophoretically either near the bodies of dorsal horn neurones, in the region of the substantia gelatinosa, or topically to the dorsal surface of the spinal cord, methysergide did not reduce supraspinal inhibition. Administered intravenously in doses of up to 2.0 mg/kg, methysergide depressed the spinal transmission of nociceptive information and reduced supraspinal inhibition. It was considered that this latter effect did not result from a blockade of the action of 5-HT released by descending fibres but rather from a depression of the firing of the cells of origin." @default.
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- W1994201515 date "1981-01-01" @default.
- W1994201515 modified "2023-09-23" @default.
- W1994201515 title "Methysergide and supraspinal inhibition of the spinal transmission of nociceptive information in the anaesthetized cat" @default.
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- W1994201515 doi "https://doi.org/10.1016/0006-8993(81)90658-2" @default.
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