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- W1994202365 endingPage "610" @default.
- W1994202365 startingPage "599" @default.
- W1994202365 abstract "This review focuses on one of the key factors accounting for differences in drug/metabolite exposure in paediatric and elderly subjects compared with that of the adult population, that is, differences in drug metabolism (both qualitative and quantitative) and in particular differences due to changes in the activity and/or concentration of drug metabolizing enzymes. Important differences have been found in the paediatric population compared with adults for both phase I (e.g. CYP3A7 versus CYP3A4 and CYP1A2, reductive and hydrolytic enzymes) and phase II (e.g. glucuronosyltransferases) enzymes. In the elderly, some phase I enzymes (e.g. esterases) appear to be impaired. From the information collected thus far, it would appear that phase II reactions, though sometimes decreased, are not extensively affected by old age." @default.
- W1994202365 created "2016-06-24" @default.
- W1994202365 creator A5003140724 @default.
- W1994202365 creator A5038156735 @default.
- W1994202365 creator A5062765056 @default.
- W1994202365 date "2007-08-01" @default.
- W1994202365 modified "2023-10-14" @default.
- W1994202365 title "Drug metabolism in the paediatric population and in the elderly" @default.
- W1994202365 cites W131196824 @default.
- W1994202365 cites W132256755 @default.
- W1994202365 cites W1514004231 @default.
- W1994202365 cites W1538110087 @default.
- W1994202365 cites W1574374367 @default.
- W1994202365 cites W169157119 @default.
- W1994202365 cites W1727274417 @default.
- W1994202365 cites W1778135744 @default.
- W1994202365 cites W1822059636 @default.
- W1994202365 cites W1847807496 @default.
- W1994202365 cites W1859059661 @default.
- W1994202365 cites W1878142115 @default.
- W1994202365 cites W1931708045 @default.
- W1994202365 cites W1965270391 @default.
- W1994202365 cites W1966050415 @default.
- W1994202365 cites W1966595871 @default.
- W1994202365 cites W1967057536 @default.
- W1994202365 cites W1968101595 @default.
- W1994202365 cites W1968464659 @default.
- W1994202365 cites W1973715596 @default.
- W1994202365 cites W1981646537 @default.
- W1994202365 cites W1984189311 @default.
- W1994202365 cites W1985901897 @default.
- W1994202365 cites W1988853236 @default.
- W1994202365 cites W1990700248 @default.
- W1994202365 cites W1990795705 @default.
- W1994202365 cites W1991287426 @default.
- W1994202365 cites W1991300596 @default.
- W1994202365 cites W1993528987 @default.
- W1994202365 cites W1994501584 @default.
- W1994202365 cites W1997547387 @default.
- W1994202365 cites W1999153032 @default.
- W1994202365 cites W2000601243 @default.
- W1994202365 cites W2001594156 @default.
- W1994202365 cites W2003094270 @default.
- W1994202365 cites W2006144160 @default.
- W1994202365 cites W2006329014 @default.
- W1994202365 cites W2007221068 @default.
- W1994202365 cites W2013833048 @default.
- W1994202365 cites W2015436686 @default.
- W1994202365 cites W2017346730 @default.
- W1994202365 cites W2018358374 @default.
- W1994202365 cites W2023358975 @default.
- W1994202365 cites W2026510672 @default.
- W1994202365 cites W2027183498 @default.
- W1994202365 cites W2029703893 @default.
- W1994202365 cites W2031141890 @default.
- W1994202365 cites W2031937669 @default.
- W1994202365 cites W2037162051 @default.
- W1994202365 cites W2041539882 @default.
- W1994202365 cites W2043455776 @default.
- W1994202365 cites W2046232265 @default.
- W1994202365 cites W2049347800 @default.
- W1994202365 cites W2059623973 @default.
- W1994202365 cites W2060967129 @default.
- W1994202365 cites W2063020863 @default.
- W1994202365 cites W2064883756 @default.
- W1994202365 cites W2066217235 @default.
- W1994202365 cites W2067384850 @default.
- W1994202365 cites W2071348846 @default.
- W1994202365 cites W2071693879 @default.
- W1994202365 cites W2073747924 @default.
- W1994202365 cites W2074361153 @default.
- W1994202365 cites W2076659619 @default.
- W1994202365 cites W2082227180 @default.
- W1994202365 cites W2085373537 @default.
- W1994202365 cites W2087008778 @default.
- W1994202365 cites W2089541112 @default.
- W1994202365 cites W2089716907 @default.
- W1994202365 cites W2090163888 @default.
- W1994202365 cites W2090678963 @default.
- W1994202365 cites W2091753882 @default.
- W1994202365 cites W2092469024 @default.
- W1994202365 cites W2094182929 @default.
- W1994202365 cites W2094367561 @default.
- W1994202365 cites W2103020094 @default.
- W1994202365 cites W2114542242 @default.
- W1994202365 cites W2120335581 @default.
- W1994202365 cites W2122481217 @default.
- W1994202365 cites W2123158196 @default.
- W1994202365 cites W2125347746 @default.
- W1994202365 cites W2144994372 @default.
- W1994202365 cites W2145542533 @default.
- W1994202365 cites W2146159727 @default.
- W1994202365 cites W2154548134 @default.
- W1994202365 cites W2155268095 @default.
- W1994202365 cites W2157997481 @default.
- W1994202365 cites W2160088797 @default.
- W1994202365 cites W2161213051 @default.
- W1994202365 cites W2207356580 @default.