FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994202396> ?p ?o ?g. }

• W1994202396 abstract "Population isolates are characterized by simplified genetic background and as such present promising opportunities for studying complex diseases. We performed a genome-wide linkage analysis for systolic (SBP) and diastolic blood pressure (DBP) followed up by the association analysis in the Croatian isolated island of Vis, where a very high prevalence of hypertension was reported (75%).Variance-components linkage analysis was used to map quantitative trait loci (QTL) for SBP and DBP in 125 families with 1,389 members. Follow-up association analysis was performed in a sample of 421 subjects from the island of Vis. The 15 top-ranking single nucleotide polymorphisms (SNPs) were selected and tested for the association by in silico replication in the British 1958 Birth Cohort DNA Collection.Linkage results showed evidence for a QTL influencing DBP (lod = 1.89) on chromosome 7p14.2 and two QTL influencing SBP (lod = 2.03 on chromosome 1p36 and lod = 1.75 on chromosome 20q13). For the association results, the replication was observed for the rs237484 polymorphism on chromosome 20 that was associated with SBP with the effect size beta = -5.2 (P = 0.001; per A allele) in Vis population and beta = -1.1 (P = 0.04) in the British 1958 Birth Cohort. rs237484 is in proximity to the potassium voltage gate channel gene (KCNB1) and close to the prostaglandin I2 (prostacyclin) synthase gene (PTGIS).These results provide evidence of a QTL influencing blood pressure (BP) variability in this region and support the notion that the isolated population of the island of Vis is a suitable population for conducting linkage and association analyses of cardiovascular-related phenotypes." @default.
• W1994202396 created "2016-06-24" @default.
• W1994202396 creator A5000636208 @default.
• W1994202396 creator A5010904497 @default.
• W1994202396 creator A5026146821 @default.
• W1994202396 creator A5035088752 @default.
• W1994202396 creator A5038431304 @default.
• W1994202396 creator A5045782628 @default.
• W1994202396 creator A5050574230 @default.
• W1994202396 creator A5051913980 @default.
• W1994202396 creator A5063119535 @default.
• W1994202396 creator A5070568170 @default.
• W1994202396 creator A5085317534 @default.
• W1994202396 creator A5086406736 @default.
• W1994202396 creator A5089705928 @default.
• W1994202396 date "2009-06-01" @default.
• W1994202396 modified "2023-10-15" @default.
• W1994202396 title "A Quantitative Trait Locus for SBP Maps Near KCNB1 and PTGIS in a Population Isolate" @default.
• W1994202396 cites W1554372034 @default.
• W1994202396 cites W1557094818 @default.
• W1994202396 cites W1984960406 @default.
• W1994202396 cites W1999908627 @default.
• W1994202396 cites W2010496617 @default.
• W1994202396 cites W2013526262 @default.
• W1994202396 cites W2019833822 @default.
• W1994202396 cites W2033179079 @default.
• W1994202396 cites W2034518797 @default.
• W1994202396 cites W2038368878 @default.
• W1994202396 cites W2053114866 @default.
• W1994202396 cites W2059826926 @default.
• W1994202396 cites W2071371198 @default.
• W1994202396 cites W2073275145 @default.
• W1994202396 cites W2074094315 @default.
• W1994202396 cites W2074539607 @default.
• W1994202396 cites W2078947233 @default.
• W1994202396 cites W2079806617 @default.
• W1994202396 cites W2080105198 @default.
• W1994202396 cites W2100989617 @default.
• W1994202396 cites W2115335486 @default.
• W1994202396 cites W2122111235 @default.
• W1994202396 cites W2122143006 @default.
• W1994202396 cites W2134890298 @default.
• W1994202396 cites W2139294259 @default.
• W1994202396 cites W2144265893 @default.
• W1994202396 cites W2144782238 @default.
• W1994202396 cites W2149586762 @default.
• W1994202396 cites W2161935988 @default.
• W1994202396 cites W2167489708 @default.
• W1994202396 cites W2131217480 @default.
• W1994202396 doi "https://doi.org/10.1038/ajh.2009.46" @default.
• W1994202396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19265782" @default.
• W1994202396 hasPublicationYear "2009" @default.
• W1994202396 type Work @default.
• W1994202396 sameAs 1994202396 @default.
• W1994202396 citedByCount "4" @default.
• W1994202396 countsByYear W19942023962013 @default.
• W1994202396 countsByYear W19942023962014 @default.
• W1994202396 crossrefType "journal-article" @default.
• W1994202396 hasAuthorship W1994202396A5000636208 @default.
• W1994202396 hasAuthorship W1994202396A5010904497 @default.
• W1994202396 hasAuthorship W1994202396A5026146821 @default.
• W1994202396 hasAuthorship W1994202396A5035088752 @default.
• W1994202396 hasAuthorship W1994202396A5038431304 @default.
• W1994202396 hasAuthorship W1994202396A5045782628 @default.
• W1994202396 hasAuthorship W1994202396A5050574230 @default.
• W1994202396 hasAuthorship W1994202396A5051913980 @default.
• W1994202396 hasAuthorship W1994202396A5063119535 @default.
• W1994202396 hasAuthorship W1994202396A5070568170 @default.
• W1994202396 hasAuthorship W1994202396A5085317534 @default.
• W1994202396 hasAuthorship W1994202396A5086406736 @default.
• W1994202396 hasAuthorship W1994202396A5089705928 @default.
• W1994202396 hasBestOaLocation W19942023961 @default.
• W1994202396 hasConcept C104317684 @default.
• W1994202396 hasConcept C106208931 @default.
• W1994202396 hasConcept C135763542 @default.
• W1994202396 hasConcept C142870003 @default.
• W1994202396 hasConcept C153209595 @default.
• W1994202396 hasConcept C186413461 @default.
• W1994202396 hasConcept C2908647359 @default.
• W1994202396 hasConcept C54355233 @default.
• W1994202396 hasConcept C69991583 @default.
• W1994202396 hasConcept C71924100 @default.
• W1994202396 hasConcept C81941488 @default.
• W1994202396 hasConcept C84597430 @default.
• W1994202396 hasConcept C86803240 @default.
• W1994202396 hasConcept C99454951 @default.
• W1994202396 hasConceptScore W1994202396C104317684 @default.
• W1994202396 hasConceptScore W1994202396C106208931 @default.
• W1994202396 hasConceptScore W1994202396C135763542 @default.
• W1994202396 hasConceptScore W1994202396C142870003 @default.
• W1994202396 hasConceptScore W1994202396C153209595 @default.
• W1994202396 hasConceptScore W1994202396C186413461 @default.
• W1994202396 hasConceptScore W1994202396C2908647359 @default.
• W1994202396 hasConceptScore W1994202396C54355233 @default.
• W1994202396 hasConceptScore W1994202396C69991583 @default.
• W1994202396 hasConceptScore W1994202396C71924100 @default.
• W1994202396 hasConceptScore W1994202396C81941488 @default.
• W1994202396 hasConceptScore W1994202396C84597430 @default.
• W1994202396 hasConceptScore W1994202396C86803240 @default.
• W1994202396 hasConceptScore W1994202396C99454951 @default.

• next