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- W1994222007 abstract "The antineoplastic agent fotemustine is shown to be a base-pair mutagen to Salmonella. Activity is more marked in the uvrB-proficient strain G46 than in the repair-deficient strain TA1535. This is consistent with its ability to cross-link DNA. Potent activity as a somatic and germ-cell mutagen to Drosophila was also observed. A potent clastogenic response was given by fotemustine in the mouse bone marrow following either oral gavage or intraperitoneal injection of a single of 5 mg/kg. In each of these respects it is shown to be indistinguishable from the structurally related antineoplastic agent and human carcinogen MeCCNU. It is concluded that fotemustine should be regarded as having clear potential to induce cancer in humans. Based on these data, including preponderance of chromosome breakages over recessive lethal mutations in Drosophila, an estimated rodent carcinogenic potency (TD50) of between 15–150 mg/kg is suggested for fotemustine." @default.
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- W1994222007 date "1983-03-01" @default.
- W1994222007 modified "2023-10-18" @default.
- W1994222007 title "Interindividual variation of cytogenetic damage by cytostatic therapy" @default.
- W1994222007 doi "https://doi.org/10.1016/0165-1161(83)90070-5" @default.
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