Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994227923> ?p ?o ?g. }
- W1994227923 endingPage "397" @default.
- W1994227923 startingPage "390" @default.
- W1994227923 abstract "Abstract Background and Objectives Photodynamic therapy (PDT) mediated with Tookad (Pd‐bacteriopheophorbide, WST09) was investigated pre‐clinically as part of a program to develop an alternative modality for treating prostate cancer. Study Design/Materials and Methods Spontaneous canine prostate cancer and normal canine prostate were used as the animal models. Interstitial PDT was performed by IV infusion of the photosensitizer and irradiating the prostates with a diode laser (763 nm). The prostates were harvested 1‐week post‐PDT and subjected to histopathologic examinations. The effects of the drug doses and light doses were studied for one‐ and two‐session PDT. Pharmacokinetics were studied using HPLC assay. The feasibility of using perfusing CT scans for assessing PDT lesions was also evaluated. Results Tookad is a vascular‐acting drug and clears rapidly from the circulation. Tookad‐PDT‐induced lesions, in both normal and cancerous prostates, were characterized by marked hemorrhagic necrosis. Conclusions Tookad‐PDT is very effective in ablating prostatic tissue through its vascular effects. Lasers Surg. Med. © 2005 Wiley‐Liss, Inc." @default.
- W1994227923 created "2016-06-24" @default.
- W1994227923 creator A5000608974 @default.
- W1994227923 creator A5001338867 @default.
- W1994227923 creator A5012571820 @default.
- W1994227923 creator A5014787098 @default.
- W1994227923 creator A5017073607 @default.
- W1994227923 creator A5035760028 @default.
- W1994227923 creator A5061907099 @default.
- W1994227923 creator A5076429572 @default.
- W1994227923 creator A5080602355 @default.
- W1994227923 date "2005-04-26" @default.
- W1994227923 modified "2023-10-15" @default.
- W1994227923 title "Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer" @default.
- W1994227923 cites W1620448903 @default.
- W1994227923 cites W1833895897 @default.
- W1994227923 cites W1965478861 @default.
- W1994227923 cites W1967585504 @default.
- W1994227923 cites W1970455217 @default.
- W1994227923 cites W1982898179 @default.
- W1994227923 cites W1998735492 @default.
- W1994227923 cites W1999673336 @default.
- W1994227923 cites W2001096293 @default.
- W1994227923 cites W2011195271 @default.
- W1994227923 cites W2016586262 @default.
- W1994227923 cites W2016773607 @default.
- W1994227923 cites W2025359238 @default.
- W1994227923 cites W2032452990 @default.
- W1994227923 cites W2035657745 @default.
- W1994227923 cites W2053764874 @default.
- W1994227923 cites W2056040379 @default.
- W1994227923 cites W2057003107 @default.
- W1994227923 cites W2058680827 @default.
- W1994227923 cites W2069739848 @default.
- W1994227923 cites W2070524517 @default.
- W1994227923 cites W2073414584 @default.
- W1994227923 cites W2075236275 @default.
- W1994227923 cites W2076635097 @default.
- W1994227923 cites W2077980483 @default.
- W1994227923 cites W2081190733 @default.
- W1994227923 cites W2088575222 @default.
- W1994227923 cites W2091210609 @default.
- W1994227923 cites W2093496215 @default.
- W1994227923 cites W2093529591 @default.
- W1994227923 cites W2111784435 @default.
- W1994227923 cites W2115914766 @default.
- W1994227923 cites W2130375917 @default.
- W1994227923 cites W2132656514 @default.
- W1994227923 cites W2133549869 @default.
- W1994227923 cites W2143378265 @default.
- W1994227923 cites W2340534380 @default.
- W1994227923 cites W2395142870 @default.
- W1994227923 cites W4230013121 @default.
- W1994227923 cites W4233634800 @default.
- W1994227923 cites W4251016016 @default.
- W1994227923 cites W77832941 @default.
- W1994227923 doi "https://doi.org/10.1002/lsm.20177" @default.
- W1994227923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1201403" @default.
- W1994227923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15856509" @default.
- W1994227923 hasPublicationYear "2005" @default.
- W1994227923 type Work @default.
- W1994227923 sameAs 1994227923 @default.
- W1994227923 citedByCount "73" @default.
- W1994227923 countsByYear W19942279232012 @default.
- W1994227923 countsByYear W19942279232013 @default.
- W1994227923 countsByYear W19942279232014 @default.
- W1994227923 countsByYear W19942279232015 @default.
- W1994227923 countsByYear W19942279232016 @default.
- W1994227923 countsByYear W19942279232017 @default.
- W1994227923 countsByYear W19942279232018 @default.
- W1994227923 countsByYear W19942279232019 @default.
- W1994227923 countsByYear W19942279232020 @default.
- W1994227923 countsByYear W19942279232021 @default.
- W1994227923 countsByYear W19942279232022 @default.
- W1994227923 crossrefType "journal-article" @default.
- W1994227923 hasAuthorship W1994227923A5000608974 @default.
- W1994227923 hasAuthorship W1994227923A5001338867 @default.
- W1994227923 hasAuthorship W1994227923A5012571820 @default.
- W1994227923 hasAuthorship W1994227923A5014787098 @default.
- W1994227923 hasAuthorship W1994227923A5017073607 @default.
- W1994227923 hasAuthorship W1994227923A5035760028 @default.
- W1994227923 hasAuthorship W1994227923A5061907099 @default.
- W1994227923 hasAuthorship W1994227923A5076429572 @default.
- W1994227923 hasAuthorship W1994227923A5080602355 @default.
- W1994227923 hasBestOaLocation W19942279232 @default.
- W1994227923 hasConcept C112705442 @default.
- W1994227923 hasConcept C121608353 @default.
- W1994227923 hasConcept C126322002 @default.
- W1994227923 hasConcept C126894567 @default.
- W1994227923 hasConcept C142724271 @default.
- W1994227923 hasConcept C178790620 @default.
- W1994227923 hasConcept C185592680 @default.
- W1994227923 hasConcept C2776235491 @default.
- W1994227923 hasConcept C2780192828 @default.
- W1994227923 hasConcept C2781323092 @default.
- W1994227923 hasConcept C2781469039 @default.
- W1994227923 hasConcept C71924100 @default.
- W1994227923 hasConceptScore W1994227923C112705442 @default.