FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994231225> ?p ?o ?g. }

• W1994231225 endingPage "1024" @default.
• W1994231225 startingPage "1015" @default.
• W1994231225 abstract "CJ-17,493 (4) is a chiral NK-1 receptor antagonist. It was first prepared through a diastereoselective crystallization, then through chiral chromatography of a key intermediate, and ultimately via asymmetric synthesis. Multiple routes for the preparation of a key isochroman were demonstrated, and conditions for improved regioselectivity of a Friedel–Crafts acylation were identified. Cesium fluoride was found to be an acceptable initiator for the generation of a nucleophilic trifluoromethyl anion from CF3TMS. A cinchonine-derived catalyst was identified for the enantioselective addition of the trifluoromethyl group to the ketone, and it was found that the product of the addition would be converted directly to the isochroman by treatment with t-BuOK. A Duff reaction was used for the formylation, and the resulting aldehyde was coupled to amine 5 to afford CJ-17,493 (4)." @default.
• W1994231225 created "2016-06-24" @default.
• W1994231225 creator A5013172876 @default.
• W1994231225 creator A5032139227 @default.
• W1994231225 creator A5038795067 @default.
• W1994231225 creator A5040464254 @default.
• W1994231225 creator A5071295313 @default.
• W1994231225 date "2007-10-30" @default.
• W1994231225 modified "2023-10-13" @default.
• W1994231225 title "Process Research and Development of an NK-1 Receptor Antagonist. Enantioselective Trifluoromethyl Addition to a Ketone in the Preparation of a Chiral Isochroman" @default.
• W1994231225 cites W1965120492 @default.
• W1994231225 cites W1976596763 @default.
• W1994231225 cites W1977074942 @default.
• W1994231225 cites W1978080244 @default.
• W1994231225 cites W1980410049 @default.
• W1994231225 cites W1982130919 @default.
• W1994231225 cites W1991065324 @default.
• W1994231225 cites W1999593025 @default.
• W1994231225 cites W2002525008 @default.
• W1994231225 cites W2003681555 @default.
• W1994231225 cites W2009661994 @default.
• W1994231225 cites W2016731880 @default.
• W1994231225 cites W2018048919 @default.
• W1994231225 cites W2026022639 @default.
• W1994231225 cites W2039563177 @default.
• W1994231225 cites W2042415587 @default.
• W1994231225 cites W2060231012 @default.
• W1994231225 cites W2150084075 @default.
• W1994231225 cites W2321634691 @default.
• W1994231225 cites W2324012446 @default.
• W1994231225 cites W2949560191 @default.
• W1994231225 cites W2950197149 @default.
• W1994231225 cites W2951770012 @default.
• W1994231225 cites W2951835496 @default.
• W1994231225 cites W2953278621 @default.
• W1994231225 doi "https://doi.org/10.1021/op7001886" @default.
• W1994231225 hasPublicationYear "2007" @default.
• W1994231225 type Work @default.
• W1994231225 sameAs 1994231225 @default.
• W1994231225 citedByCount "68" @default.
• W1994231225 countsByYear W19942312252012 @default.
• W1994231225 countsByYear W19942312252013 @default.
• W1994231225 countsByYear W19942312252014 @default.
• W1994231225 countsByYear W19942312252015 @default.
• W1994231225 countsByYear W19942312252016 @default.
• W1994231225 countsByYear W19942312252017 @default.
• W1994231225 countsByYear W19942312252018 @default.
• W1994231225 countsByYear W19942312252019 @default.
• W1994231225 countsByYear W19942312252020 @default.
• W1994231225 countsByYear W19942312252021 @default.
• W1994231225 countsByYear W19942312252022 @default.
• W1994231225 countsByYear W19942312252023 @default.
• W1994231225 crossrefType "journal-article" @default.
• W1994231225 hasAuthorship W1994231225A5013172876 @default.
• W1994231225 hasAuthorship W1994231225A5032139227 @default.
• W1994231225 hasAuthorship W1994231225A5038795067 @default.
• W1994231225 hasAuthorship W1994231225A5040464254 @default.
• W1994231225 hasAuthorship W1994231225A5071295313 @default.
• W1994231225 hasConcept C138716334 @default.
• W1994231225 hasConcept C146686406 @default.
• W1994231225 hasConcept C161790260 @default.
• W1994231225 hasConcept C178790620 @default.
• W1994231225 hasConcept C178907741 @default.
• W1994231225 hasConcept C185592680 @default.
• W1994231225 hasConcept C21951064 @default.
• W1994231225 hasConcept C2776171072 @default.
• W1994231225 hasConcept C2776442012 @default.
• W1994231225 hasConcept C2777243832 @default.
• W1994231225 hasConcept C2777738585 @default.
• W1994231225 hasConcept C2779155132 @default.
• W1994231225 hasConcept C2779825165 @default.
• W1994231225 hasConcept C2780263894 @default.
• W1994231225 hasConcept C59759590 @default.
• W1994231225 hasConceptScore W1994231225C138716334 @default.
• W1994231225 hasConceptScore W1994231225C146686406 @default.
• W1994231225 hasConceptScore W1994231225C161790260 @default.
• W1994231225 hasConceptScore W1994231225C178790620 @default.
• W1994231225 hasConceptScore W1994231225C178907741 @default.
• W1994231225 hasConceptScore W1994231225C185592680 @default.
• W1994231225 hasConceptScore W1994231225C21951064 @default.
• W1994231225 hasConceptScore W1994231225C2776171072 @default.
• W1994231225 hasConceptScore W1994231225C2776442012 @default.
• W1994231225 hasConceptScore W1994231225C2777243832 @default.
• W1994231225 hasConceptScore W1994231225C2777738585 @default.
• W1994231225 hasConceptScore W1994231225C2779155132 @default.
• W1994231225 hasConceptScore W1994231225C2779825165 @default.
• W1994231225 hasConceptScore W1994231225C2780263894 @default.
• W1994231225 hasConceptScore W1994231225C59759590 @default.
• W1994231225 hasIssue "6" @default.
• W1994231225 hasLocation W19942312251 @default.
• W1994231225 hasOpenAccess W1994231225 @default.
• W1994231225 hasPrimaryLocation W19942312251 @default.
• W1994231225 hasRelatedWork W1994231225 @default.
• W1994231225 hasRelatedWork W2015967119 @default.
• W1994231225 hasRelatedWork W2052040736 @default.
• W1994231225 hasRelatedWork W2071871676 @default.
• W1994231225 hasRelatedWork W2149404087 @default.
• W1994231225 hasRelatedWork W2154956352 @default.

• next