FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994243119> ?p ?o ?g. }

• W1994243119 endingPage "825" @default.
• W1994243119 startingPage "816" @default.
• W1994243119 abstract "The objective of this study is to demonstrate the feasibility of using solubility parameter as guidance for the design and identification of a stable micellar system with a high drug loading capacity for oral drug delivery. Using hydroxycamptothecin (HCPT) as a model drug, the effect of three hydrophobic blocks (fatty glycerides) grafted onto chitosan on the drug loading and stability of HCPT-loaded micellar nanoparticles formed by pH precipitation method were studied systematically. The Flory-Huggins interaction parameter (χFH) calculated by the group contribution method (GCM) and molecular dynamics simulation (MDS) was used to assess the compatibility between HCPT and the copolymers. The predicted order of compatibility between three chitosan derivatives and HCPT was verified experimentally. A high drug loading and remarkably stable micellar system for oral administration based on succinylated glycerol monooleate-chitosan was discovered in this study. Our study suggests that the miscibility between drug and copolymer is crucial to drug loading and stability of the micellar system. Thus, the calculation of χFH using GCM and MDS methods is useful for guiding the design or screening of a suitable copolymer for preparing drug-loaded micellar nanocarrier systems." @default.
• W1994243119 created "2016-06-24" @default.
• W1994243119 creator A5011151975 @default.
• W1994243119 creator A5022631736 @default.
• W1994243119 creator A5029740776 @default.
• W1994243119 creator A5064689994 @default.
• W1994243119 creator A5068234565 @default.
• W1994243119 creator A5091082145 @default.
• W1994243119 date "2015-02-04" @default.
• W1994243119 modified "2023-09-29" @default.
• W1994243119 title "Designing Micellar Nanocarriers with Improved Drug Loading and Stability Based on Solubility Parameter" @default.
• W1994243119 cites W1963956640 @default.
• W1994243119 cites W1965247088 @default.
• W1994243119 cites W1968436748 @default.
• W1994243119 cites W1970977603 @default.
• W1994243119 cites W1976954322 @default.
• W1994243119 cites W1981345866 @default.
• W1994243119 cites W1993506166 @default.
• W1994243119 cites W1995599137 @default.
• W1994243119 cites W2003768250 @default.
• W1994243119 cites W2013287766 @default.
• W1994243119 cites W2044074008 @default.
• W1994243119 cites W2055928148 @default.
• W1994243119 cites W2058360844 @default.
• W1994243119 cites W2062108945 @default.
• W1994243119 cites W2067291446 @default.
• W1994243119 cites W2087313309 @default.
• W1994243119 cites W2087421919 @default.
• W1994243119 cites W2087852082 @default.
• W1994243119 cites W2090355386 @default.
• W1994243119 cites W2090433937 @default.
• W1994243119 cites W2095296924 @default.
• W1994243119 cites W2115897413 @default.
• W1994243119 cites W2124131536 @default.
• W1994243119 cites W2128212379 @default.
• W1994243119 cites W2140568284 @default.
• W1994243119 cites W2156694810 @default.
• W1994243119 cites W2312702537 @default.
• W1994243119 cites W2327468846 @default.
• W1994243119 doi "https://doi.org/10.1021/mp5006504" @default.
• W1994243119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25587749" @default.
• W1994243119 hasPublicationYear "2015" @default.
• W1994243119 type Work @default.
• W1994243119 sameAs 1994243119 @default.
• W1994243119 citedByCount "48" @default.
• W1994243119 countsByYear W19942431192015 @default.
• W1994243119 countsByYear W19942431192016 @default.
• W1994243119 countsByYear W19942431192017 @default.
• W1994243119 countsByYear W19942431192018 @default.
• W1994243119 countsByYear W19942431192019 @default.
• W1994243119 countsByYear W19942431192020 @default.
• W1994243119 countsByYear W19942431192021 @default.
• W1994243119 countsByYear W19942431192022 @default.
• W1994243119 countsByYear W19942431192023 @default.
• W1994243119 crossrefType "journal-article" @default.
• W1994243119 hasAuthorship W1994243119A5011151975 @default.
• W1994243119 hasAuthorship W1994243119A5022631736 @default.
• W1994243119 hasAuthorship W1994243119A5029740776 @default.
• W1994243119 hasAuthorship W1994243119A5064689994 @default.
• W1994243119 hasAuthorship W1994243119A5068234565 @default.
• W1994243119 hasAuthorship W1994243119A5091082145 @default.
• W1994243119 hasConcept C100293340 @default.
• W1994243119 hasConcept C110884469 @default.
• W1994243119 hasConcept C11268172 @default.
• W1994243119 hasConcept C127413603 @default.
• W1994243119 hasConcept C155574463 @default.
• W1994243119 hasConcept C15920480 @default.
• W1994243119 hasConcept C178790620 @default.
• W1994243119 hasConcept C18150654 @default.
• W1994243119 hasConcept C184651966 @default.
• W1994243119 hasConcept C185592680 @default.
• W1994243119 hasConcept C192562407 @default.
• W1994243119 hasConcept C2779732960 @default.
• W1994243119 hasConcept C2779820397 @default.
• W1994243119 hasConcept C2780035454 @default.
• W1994243119 hasConcept C42360764 @default.
• W1994243119 hasConcept C43617362 @default.
• W1994243119 hasConcept C521977710 @default.
• W1994243119 hasConcept C71924100 @default.
• W1994243119 hasConcept C98274493 @default.
• W1994243119 hasConcept C98765843 @default.
• W1994243119 hasConceptScore W1994243119C100293340 @default.
• W1994243119 hasConceptScore W1994243119C110884469 @default.
• W1994243119 hasConceptScore W1994243119C11268172 @default.
• W1994243119 hasConceptScore W1994243119C127413603 @default.
• W1994243119 hasConceptScore W1994243119C155574463 @default.
• W1994243119 hasConceptScore W1994243119C15920480 @default.
• W1994243119 hasConceptScore W1994243119C178790620 @default.
• W1994243119 hasConceptScore W1994243119C18150654 @default.
• W1994243119 hasConceptScore W1994243119C184651966 @default.
• W1994243119 hasConceptScore W1994243119C185592680 @default.
• W1994243119 hasConceptScore W1994243119C192562407 @default.
• W1994243119 hasConceptScore W1994243119C2779732960 @default.
• W1994243119 hasConceptScore W1994243119C2779820397 @default.
• W1994243119 hasConceptScore W1994243119C2780035454 @default.
• W1994243119 hasConceptScore W1994243119C42360764 @default.
• W1994243119 hasConceptScore W1994243119C43617362 @default.
• W1994243119 hasConceptScore W1994243119C521977710 @default.

• next