Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994246870> ?p ?o ?g. }
- W1994246870 endingPage "179" @default.
- W1994246870 startingPage "169" @default.
- W1994246870 abstract "Childhood and adolescence are crucial times for the development of a healthy skeletal and cardiovascular system. Disordered mineral and bone metabolism accompany chronic kidney disease (CKD) and present significant obstacles to optimal bone strength, final adult height, and cardiovascular health. Early increases in bone and plasma fibroblast growth factor 23 (FGF23) are associated with early defects in skeletal mineralization. Later in the course of CKD, secondary hyperparathyroidism--caused by a combination of declining calcitriol values and phosphate retention--results in high-turnover renal osteodystrophy whereas increased levels of both phosphate and FGF23 contribute to cardiovascular disease. Treatment of hyperphosphatemia and secondary hyperparathyroidism improves high-turnover bone disease but fails to correct defects in skeletal mineralization. Because overtreatment may result in adynamic bone disease, growth failure, hypercalcemia, and progression of cardiovascular calcifications, therapy therefore must be titrated carefully to maintain optimal serum biochemical parameters according to stage of CKD. Newer therapeutic agents and new treatment paradigms may suppress serum PTH levels effectively while limiting intestinal calcium absorption and skeletal FGF23 stimulation and may provide future therapeutic alternatives for children with CKD." @default.
- W1994246870 created "2016-06-24" @default.
- W1994246870 creator A5061322949 @default.
- W1994246870 creator A5084811951 @default.
- W1994246870 date "2013-03-01" @default.
- W1994246870 modified "2023-10-16" @default.
- W1994246870 title "Chronic Kidney Disease: Mineral and Bone Disorder in Children" @default.
- W1994246870 cites W1563425273 @default.
- W1994246870 cites W1573777214 @default.
- W1994246870 cites W1590658964 @default.
- W1994246870 cites W1964403552 @default.
- W1994246870 cites W1965093148 @default.
- W1994246870 cites W1966856654 @default.
- W1994246870 cites W1967330581 @default.
- W1994246870 cites W1967759185 @default.
- W1994246870 cites W1969590424 @default.
- W1994246870 cites W1972894746 @default.
- W1994246870 cites W1973338388 @default.
- W1994246870 cites W1976544899 @default.
- W1994246870 cites W1977645780 @default.
- W1994246870 cites W1978833666 @default.
- W1994246870 cites W1979542010 @default.
- W1994246870 cites W1979587730 @default.
- W1994246870 cites W1981228902 @default.
- W1994246870 cites W1982290615 @default.
- W1994246870 cites W1986695347 @default.
- W1994246870 cites W1987586045 @default.
- W1994246870 cites W1988793415 @default.
- W1994246870 cites W1993858578 @default.
- W1994246870 cites W1993878251 @default.
- W1994246870 cites W1994596418 @default.
- W1994246870 cites W1994604536 @default.
- W1994246870 cites W1997768246 @default.
- W1994246870 cites W2000048959 @default.
- W1994246870 cites W2001619156 @default.
- W1994246870 cites W2003490678 @default.
- W1994246870 cites W2006631091 @default.
- W1994246870 cites W2008638208 @default.
- W1994246870 cites W2008678562 @default.
- W1994246870 cites W2009441758 @default.
- W1994246870 cites W2011733343 @default.
- W1994246870 cites W2013009411 @default.
- W1994246870 cites W2013913049 @default.
- W1994246870 cites W2015668150 @default.
- W1994246870 cites W2017591034 @default.
- W1994246870 cites W2018006483 @default.
- W1994246870 cites W2018429484 @default.
- W1994246870 cites W2018449400 @default.
- W1994246870 cites W2018809127 @default.
- W1994246870 cites W2020007020 @default.
- W1994246870 cites W2021610221 @default.
- W1994246870 cites W2021852822 @default.
- W1994246870 cites W2023653442 @default.
- W1994246870 cites W2030344529 @default.
- W1994246870 cites W2030777261 @default.
- W1994246870 cites W2031941775 @default.
- W1994246870 cites W2034468185 @default.
- W1994246870 cites W2037045934 @default.
- W1994246870 cites W2039127386 @default.
- W1994246870 cites W2041242683 @default.
- W1994246870 cites W2041899030 @default.
- W1994246870 cites W2042256973 @default.
- W1994246870 cites W2044497094 @default.
- W1994246870 cites W2056130683 @default.
- W1994246870 cites W2059965567 @default.
- W1994246870 cites W2063719550 @default.
- W1994246870 cites W2065763027 @default.
- W1994246870 cites W2067291932 @default.
- W1994246870 cites W2071165527 @default.
- W1994246870 cites W2076507063 @default.
- W1994246870 cites W2078817914 @default.
- W1994246870 cites W2083604596 @default.
- W1994246870 cites W2083921658 @default.
- W1994246870 cites W2084513789 @default.
- W1994246870 cites W2086412753 @default.
- W1994246870 cites W2088467187 @default.
- W1994246870 cites W2089345381 @default.
- W1994246870 cites W2091063844 @default.
- W1994246870 cites W2094013760 @default.
- W1994246870 cites W2094370796 @default.
- W1994246870 cites W2094551185 @default.
- W1994246870 cites W2094588238 @default.
- W1994246870 cites W2095233918 @default.
- W1994246870 cites W2095948376 @default.
- W1994246870 cites W2097417649 @default.
- W1994246870 cites W2098122721 @default.
- W1994246870 cites W2101662558 @default.
- W1994246870 cites W2105173544 @default.
- W1994246870 cites W2105288874 @default.
- W1994246870 cites W2105898297 @default.
- W1994246870 cites W2107795472 @default.
- W1994246870 cites W2110601215 @default.
- W1994246870 cites W2111094568 @default.
- W1994246870 cites W2111899789 @default.
- W1994246870 cites W2118179060 @default.
- W1994246870 cites W2118752987 @default.
- W1994246870 cites W2120129493 @default.
- W1994246870 cites W2121043812 @default.