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• W1994255091 abstract "Summary— Whether the influux of calcium through voltage-operated channels is involved in the stimulatory effects of substance P and neurokinin A in aiways smooth muscle is not yet firmly established. This question was addressed in the present study using guinea pig trachea and human bronchi suspended in normal or calcium-free Krebs solution and tested with inhibitors of calcium channels. In calcium-free Krebs solution, the myotropic effects of substance P (10−7 M), neurokinin A (3.10−8 M), acetylcholine (2.10−5 M), and histamine (2.10−5 M) were reduced by 27–57%, while those of potassium chloride and tetraethylammonium were practically abolished. Calcium antagonists such as verapamil or nicardipine, when applied at concentrations of 10−8-10−6 M, inhibited the contractions produced by potassium chloride and tetraethylammonium, whereas higher concentrations (10−5-10−4 M) of both inhibitors were needed to reduce the effects of substance P, neurokinin A, acetylcholine, and histamine. In neither preparation did the calcium agonist Bay K 8644 (10−6 M) modify the effects of neurokinin A, substance P, acetylcholine, or histamine, but it potentiated potassium chloride's effect on human bronchi. We conclude that transmembrane calcium influx through voltage-operated channels plays a minor role in the stimulatory effects of neurokinins in airways smooth muscle." @default.
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• W1994255091 date "1988-01-02" @default.
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• W1994255091 title "ROLE OF EXTRACELLULAR CALCIUM IN THE EFFECTS OF SUBSTANCE P AND NEUROKININ A ON GUINEA PIG TRACHEA AND HUMAN BRONCHUS" @default.
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• W1994255091 doi "https://doi.org/10.1111/j.1472-8206.1988.tb00620.x" @default.
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