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- W1994272903 abstract "Structural elements of an antibody (Ab) or antigen (Ag) distant from the actual sites mediating contact between Ab and Ag can exert substantial influence on binding to, and discrimination among, multivalent targets. Consequently, multivalent molecules that express the same number of identical binding sites, but that differ in other structural features, can exhibit differences in their ability to discriminate between multivalent ligands. Here, Neil Greenspan and Laurence Cooper review evidence for these effects, and explore implications of the conclusion that effective specificity in multivalent interactions is not completely determined by the degree of complementarity between epitopes and paratopes." @default.
- W1994272903 created "2016-06-24" @default.
- W1994272903 creator A5006973068 @default.
- W1994272903 creator A5007081796 @default.
- W1994272903 date "1995-01-01" @default.
- W1994272903 modified "2023-09-27" @default.
- W1994272903 title "Complementarity, specificity and the nature of epitopes and paratopes in multivalent intereactions" @default.
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- W1994272903 doi "https://doi.org/10.1016/0167-5699(95)80164-2" @default.
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