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- W1994289916 abstract "Electrical stimulation of brain results in an enhancement of glycogen breakdown (King, Lowry, Passonneau and Venson, 1967) and one should therefore expect exitation to be linked in some way to glycogen metabolism. Stimulation of muscle cells, which induces contraction, also increases glycogen breakdown. In this case it has been shown that a minute amount of Ca2+, which couples excitation and contraction, also serves as a link between excitation and glycogenolysis (Ozawa, Hosoi and Ebashi, 1967). A small amount of Ca2+, released into the sarcoplasm as a result of excitation of the cell membrane, activates phosphorylase kinase. The activated kinase, in turn, converts phosphorylase α (the inactive form of phosphorylase) to phosphorylasea (the active form). The present communication summarizes the evidence that a similar mechanism operates in brain." @default.
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- W1994289916 date "1973-05-01" @default.
- W1994289916 modified "2023-10-16" @default.
- W1994289916 title "Activation of phosphorylase kinase from brain by small amounts of calcium ion" @default.
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- W1994289916 doi "https://doi.org/10.1111/j.1471-4159.1973.tb00263.x" @default.
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