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• W1994291234 abstract "We have previously shown that α and β adrenoceptor agonists injected intraventricularly and intrahypothalamically elicit feeding in sheep and only β agonists readily elicit feeding in cattle. In the present work sheep and cattle, surgically prepared with lateral ventricular guides, were injected during 70 sec with 1.0 ml synthetic CSF with or without drug on experimental days. The animals were fed ad lib and fresh feed was given 1 hr prior to the injection to synchronize spontaneous meals. Injections of 1-Epi, a universal adrenoceptor agonist, into sheep elicited feeding with doses of 33 to 66 nmoles and with higher doses of 267–534 nmoles; the lower dose range was similar to that required of dl-isoproterenol (dl-Isop), a β agonist, and the higher dose range was similar to that required of 1-NE, an α agonist, to elicit feeding. The response to the upper range of 1-Epi was specifically blocked by an α antagonist, phenoxybenzamine. Responses to the lower range were blocked, in part, by both α and β antagonists. Precursors of 1-NE and 1-Epi, i.e., 1-Dopa and dopamine, did not elicit feeding in the same dose ranges as the products. More selective β agonist ( β 2 ) were less potent for eliciting feeding than dl-Isop. In cattle, 1-Epi did not elicit reliable feeding, although 7 doses were tested ranging from 50–3,240 nmoles. All of the feeding responses in sheep occurred at lower doses than those required for changes in body temperature. These data lend additional support and characterization to our previous conclusion that feeding in sheep can be elicited by both α and β adrenoceptor agonists, but the latter are much more potent. Agonists with α activity do not readily elicit feeding in cattle." @default.
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• W1994291234 date "1973-09-01" @default.
• W1994291234 modified "2023-09-25" @default.
• W1994291234 title "Feeding elicited by α and β adrenoceptor agonists in sheep and cattle" @default.
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• W1994291234 doi "https://doi.org/10.1016/0091-3057(73)90077-4" @default.
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