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- W1994293409 abstract "Photokilling depends on the generation of death signals after photosensitized cells are irradiated. A variety of intracellularorganelles can be targeted for photodamage, often with a high degree of specificity. We have discovered that a low levelof photodamage directed against lysosomes can sensitize both a murine hepatoma cell line (in 2D culture) and aninflammatory breast cancer line of human origin (in a 3D model) to subsequent photodamage directed at mitochondria.Additional studies were carried out with hepatoma cells to explore possible mechanisms. The phototoxic effect of the‘sequential targeting’ approach was associated with an increased apoptotic response. The low level of lysosomalphotodamage did not lead to any detectable migration of Fe ++ from lysosomes to mitochondria or increased reactive oxygen species (ROS) formation after subsequent mitochondrial photodamage. Instead, there appears to be a signal generated thatcan amplify the pro-apoptotic effect of subsequent mitochondrial photodamage." @default.
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- W1994293409 date "2014-03-05" @default.
- W1994293409 modified "2023-09-23" @default.
- W1994293409 title "Increased efficacy of photodynamic therapy via sequential targeting" @default.
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- W1994293409 doi "https://doi.org/10.1117/12.2042421" @default.
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