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- W1994295729 abstract "Advanced computer technology can be used to design and customize a Trachea-Esophageal Puncture (TEP) voice prosthesis for speech restoration. Current voice prostheses have a standard range of sizes and shape that do not cater for all patients. This causes issues such as transprosthetic and periprosthetic leakages due to poor valve closure and misfit of the prosthesis in the patient's fistula respectively. To address these limitations, we present a Computer Aided Design (CAD) methodology that utilizes patient's imaging data, simulations and rapid prototyping to develop the world's first patient-specific carbon nanocomposite voice prosthesis. The outer skin of the device is made from Carbon Nanotube-Polydimethylsiloxane (CNT-PDMS) and is geometrically customizable to fit the patient's fistula for better seal. CAD and simulation of the prostheses based on patient-specific anatomical dimensions from imaging data are performed and evaluated. The finite element analysis results indicated that patient specificity in design produces lower and more even distribution of stress in the surrounding tissues compared to a modular cylindrical design. Flow simulations and in-vitro experiments to study the air flow resistance of the novel magnetic ball bearing valve and a range of inner diameters showed lower flow resistance compared to other types of prostheses. Finally, successful preliminary in-vivo experiments were carried out on live pig models to verify the feasibility of the patient-specific CAD methodology based on the subjects' imaging data. The in-vivo results have demonstrated a close fit of the customized device in the fistula with no leakage observed through the prosthesis when water was flushed down the esophagus. The advantages of our patient-specific voice prosthesis methodology over current methods of estimation and relying on fixed prosthesis sizes are the elimination of surgical correction to seal oversized fistulas and unnecessary multiple insertions due to incorrect sizing and misfit. This paper highlights the usefulness of assimilating patient -specific CAD as part of the voice prosthesis fabrication process to produce better healthcare quality and eliminate leakages." @default.
- W1994295729 created "2016-06-24" @default.
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- W1994295729 date "2015-02-01" @default.
- W1994295729 modified "2023-09-24" @default.
- W1994295729 title "Computer aided design and experiment of a novel patient-specific carbon nanocomposite voice prosthesis" @default.
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- W1994295729 doi "https://doi.org/10.1016/j.cad.2014.09.002" @default.
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