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- W1994297046 abstract "1 Buspirone, MJ-13805 and MJ-13653 did not produce a ‘5-hydroxytryptamine (5-HT) syndrome’ in rats at doses up to 20 mg kg−1. 2 These drugs were very weak 5-HT uptake blockers (IC50 ≫ 10 μM) compared to drugs such as chlorimipramine. 3 These drugs did not inhibit either monoamine oxidase (MAO)-A or MAO-B. 4 The Ki values for these agents as inhibitors of [3H]-5-HT and [3H]-ketanserin binding to rat frontal cortex or hippocampal membranes were in the μM range, well above the brain concentrations achieved after an oral dose of 25 mg kg−1. 5 Parenterally administered buspirone blocked apomorphine-induced sterotypy, inhibited the 5-HT syndrome elicited by 5-methoxy-N,N-dimethyltryptamine, and delayed the onset of p-chloroamphetamine induced behaviours." @default.
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- W1994297046 date "1985-11-01" @default.
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- W1994297046 title "Monoaminergic involvement in the pharmacological actions of buspirone" @default.
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- W1994297046 doi "https://doi.org/10.1111/j.1476-5381.1985.tb08940.x" @default.
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