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• W1994300672 abstract "A novel investigation into the fluorescence lifetimes of molecules, both established and newly designed, was performed. These molecules are the basis of a continuous, minimally invasive, glucose sensor based on fluorescence lifetime measurements. This sensor, if coupled with an automated insulin delivery device, would effectively create an artificial pancreas allowing for the constant monitoring and control of glucose levels in a person with diabetes. The proposed sensor includes a fluorescent molecule that changes its' fluorescence properties upon binding selectively and reversibly to glucose. One possible sensor molecule is N-methyl-N-(9-methylene anthryl)-2-methylenephenylboronic acid (AB). The fluorescence intensity of AB was shown to change in response to changing glucose concentrations. (James, 1994) James proposed that when glucose binds to AB the fluorescence intensity increases due to an enhancement of the N{yields}B dative bond which prevents photoinduced electron transfer (PET). PET from the amine (N) to the fluorophore (anthracene) quenches the fluorescence. The dative bond between the boron and the amine can prevent PET by involving the lone pair of electrons on the amine in interactions with the boron rather than allowing them to be transferred to the fluorophore. Results of this research show the average fluorescence lifetime of AB also changes with glucosemore » concentration. It is proposed that fluorescence is due to two components: (1) AB with an enhanced N{yields}B interaction, and no PET, and (2) AB with a weak N{yields}B interaction, resulting in fluorescence quenching by PET. Lifetime measurements of AB as a function of both the pH of the solvent and glucose concentration in the solution were made to characterize this two component system and investigate the nature of the N{yields}B bond. Measurements of molecules similar to AB were also performed in order to isolate behavior of specific AB constituents. These molecules are 9-(Methylaminomethyl)-anthracene (MAMA), and N-benzyl-N-methyl-N-methyl anthracene (AB-B). Fluorescence lifetime measurements confirmed the two species of AB, with and without PET. Fluorescence lifetimes were approximately 11 nsec without PET and 3 nsec with PET. The degree of the interaction between the N and the B atoms was also determined by fluorescence lifetime measurements. Electron transfer rates of AB were measured to be on the order of 10{sup 8} sec{sup -1}. Analysis of AB as a glucose sensor shows it has the potential for measuring glucose concentrations in solution with less than 5% error. Two novel glucose sensing molecules, Chloro-oxazone boronate (COB) and Napthyl-imide boronate (NIB), were synthesized. Both molecules have a N{yields}B dative bond similar to AB, but with longer wavelength fluorophores. COB and NIB were found to be unacceptable for use as glucose sensor molecules due to the small changes in average fluorescence lifetime.« less" @default.
• W1994300672 created "2016-06-24" @default.
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• W1994300672 date "2000-06-01" @default.
• W1994300672 modified "2023-09-23" @default.
• W1994300672 title "Fluorescence lifetime measurements of boronate derivatives to determine glucose concentration" @default.
• W1994300672 doi "https://doi.org/10.2172/15007221" @default.
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