Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994300899> ?p ?o ?g. }
- W1994300899 endingPage "929" @default.
- W1994300899 startingPage "919" @default.
- W1994300899 abstract "To seek direct evidence for a cause-effect relation between sympathetic activation and arrhythmogenesis.Rats underwent open-chest surgery with either coronary artery occlusion or sham operation, and were studied 8 weeks later using in situ heart perfusion and nerve stimulation methods.Infarcted rats showed cardiac functional impairment and increased heart and lung weight. The extent of these changes correlated well with infarct size (IS). In in situ perfused hearts, sympathetic nerve stimulation (2 and 4 Hz, 45 s duration) induced a frequency-dependent release of norepinephrine (NE). NE release was lower in MI than that in control groups. In hearts with large IS (> or = 40%, n = 19) ventricular arrhythmias were rare at baseline, but nerve stimulation evoked the onset of ventricular premature beats (95%), tachycardia (37%) and fibrillation (26%), IS and stimulation frequency were key determinants for the inducibility of arrhythmias. Lower K- concentration enhanced arrhythmia inducibility. beta-blockade inhibited the frequency of arrhythmias produced by nerve stimulation.In infarcted rat hearts sympathetic activation is a potent trigger for the onset of ventricular tachyarrhythmias." @default.
- W1994300899 created "2016-06-24" @default.
- W1994300899 creator A5011375886 @default.
- W1994300899 creator A5039727606 @default.
- W1994300899 creator A5058019993 @default.
- W1994300899 creator A5082586880 @default.
- W1994300899 date "1999-09-01" @default.
- W1994300899 modified "2023-10-15" @default.
- W1994300899 title "Sympathetic activation triggers ventricular arrhythmias in rat heart with chronic infarction and failure" @default.
- W1994300899 cites W1600588265 @default.
- W1994300899 cites W1932521730 @default.
- W1994300899 cites W1952889644 @default.
- W1994300899 cites W1970563581 @default.
- W1994300899 cites W1971196543 @default.
- W1994300899 cites W1974742889 @default.
- W1994300899 cites W1977859104 @default.
- W1994300899 cites W1981079849 @default.
- W1994300899 cites W1983240248 @default.
- W1994300899 cites W1984872916 @default.
- W1994300899 cites W1985977264 @default.
- W1994300899 cites W1991447854 @default.
- W1994300899 cites W1991751851 @default.
- W1994300899 cites W1991996785 @default.
- W1994300899 cites W1993457540 @default.
- W1994300899 cites W1994734582 @default.
- W1994300899 cites W1995547316 @default.
- W1994300899 cites W1996618583 @default.
- W1994300899 cites W2000991748 @default.
- W1994300899 cites W2013879872 @default.
- W1994300899 cites W20142173 @default.
- W1994300899 cites W2021941221 @default.
- W1994300899 cites W2032080137 @default.
- W1994300899 cites W2039371880 @default.
- W1994300899 cites W2042374948 @default.
- W1994300899 cites W2049264632 @default.
- W1994300899 cites W2050352369 @default.
- W1994300899 cites W2061689246 @default.
- W1994300899 cites W2064143679 @default.
- W1994300899 cites W2068705524 @default.
- W1994300899 cites W2070857612 @default.
- W1994300899 cites W2076443361 @default.
- W1994300899 cites W2088748576 @default.
- W1994300899 cites W2088901422 @default.
- W1994300899 cites W2095168948 @default.
- W1994300899 cites W2096673028 @default.
- W1994300899 cites W2132160350 @default.
- W1994300899 cites W2132603512 @default.
- W1994300899 cites W2133488495 @default.
- W1994300899 cites W2137625635 @default.
- W1994300899 cites W2141790142 @default.
- W1994300899 cites W2145324521 @default.
- W1994300899 cites W2316096120 @default.
- W1994300899 cites W2326508838 @default.
- W1994300899 cites W2335190662 @default.
- W1994300899 cites W2401178172 @default.
- W1994300899 cites W2416149566 @default.
- W1994300899 cites W2462578339 @default.
- W1994300899 cites W2501507765 @default.
- W1994300899 cites W2835846723 @default.
- W1994300899 cites W2888788610 @default.
- W1994300899 cites W60084911 @default.
- W1994300899 cites W66476485 @default.
- W1994300899 doi "https://doi.org/10.1016/s0008-6363(99)00139-x" @default.
- W1994300899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10615419" @default.
- W1994300899 hasPublicationYear "1999" @default.
- W1994300899 type Work @default.
- W1994300899 sameAs 1994300899 @default.
- W1994300899 citedByCount "81" @default.
- W1994300899 countsByYear W19943008992012 @default.
- W1994300899 countsByYear W19943008992013 @default.
- W1994300899 countsByYear W19943008992014 @default.
- W1994300899 countsByYear W19943008992015 @default.
- W1994300899 countsByYear W19943008992016 @default.
- W1994300899 countsByYear W19943008992017 @default.
- W1994300899 countsByYear W19943008992018 @default.
- W1994300899 countsByYear W19943008992019 @default.
- W1994300899 countsByYear W19943008992020 @default.
- W1994300899 countsByYear W19943008992021 @default.
- W1994300899 countsByYear W19943008992022 @default.
- W1994300899 countsByYear W19943008992023 @default.
- W1994300899 crossrefType "journal-article" @default.
- W1994300899 hasAuthorship W1994300899A5011375886 @default.
- W1994300899 hasAuthorship W1994300899A5039727606 @default.
- W1994300899 hasAuthorship W1994300899A5058019993 @default.
- W1994300899 hasAuthorship W1994300899A5082586880 @default.
- W1994300899 hasBestOaLocation W19943008991 @default.
- W1994300899 hasConcept C126322002 @default.
- W1994300899 hasConcept C146957229 @default.
- W1994300899 hasConcept C164705383 @default.
- W1994300899 hasConcept C24998067 @default.
- W1994300899 hasConcept C2776331378 @default.
- W1994300899 hasConcept C2776533406 @default.
- W1994300899 hasConcept C2777798775 @default.
- W1994300899 hasConcept C2778198053 @default.
- W1994300899 hasConcept C2780283014 @default.
- W1994300899 hasConcept C2781005686 @default.
- W1994300899 hasConcept C42219234 @default.
- W1994300899 hasConcept C500558357 @default.