FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994304911> ?p ?o ?g. }

• W1994304911 endingPage "4260" @default.
• W1994304911 startingPage "4253" @default.
• W1994304911 abstract "Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder that occurs with variable frequency in patients exposed to heparin. HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical properties of complexes that initiate antibody production are unknown. To identify structural determinants underlying PF4/heparin immunogenicity, we characterized the in vitro interactions of murine PF4 (mPF4) and heparin with respect to light absorption, size, and surface charge (zeta potential). We show that PF4/heparin macromolecular assembly occurs through colloidal interactions, wherein heparin facilitates the growth of complexes through charge neutralization. The size of PF4/heparin macromolecules is governed by the molar ratios of the reactants. Maximal complex size occurs at molar ratios of PF4/heparin at which surface charge is neutral. When mice are immunized with complexes that differ in size and/or zeta potential, antibody formation varies inversely with heparin concentration and is most robust in animals immunized with complexes displaying a net positive zeta-potential. These studies suggest that the clinical heterogeneity in the HIT immune response may be due in part to requirements for specific biophysical parameters of the PF4/heparin complexes that occur in settings of intense platelet activation and PF4 release." @default.
• W1994304911 created "2016-06-24" @default.
• W1994304911 creator A5027879891 @default.
• W1994304911 creator A5030315782 @default.
• W1994304911 creator A5032758552 @default.
• W1994304911 creator A5040851400 @default.
• W1994304911 creator A5070445093 @default.
• W1994304911 creator A5075920531 @default.
• W1994304911 creator A5077478635 @default.
• W1994304911 creator A5086984176 @default.
• W1994304911 date "2007-12-15" @default.
• W1994304911 modified "2023-09-27" @default.
• W1994304911 title "Determinants of PF4/heparin immunogenicity" @default.
• W1994304911 cites W1563836404 @default.
• W1994304911 cites W1892579436 @default.
• W1994304911 cites W1964636146 @default.
• W1994304911 cites W1969633857 @default.
• W1994304911 cites W1983285135 @default.
• W1994304911 cites W1990893901 @default.
• W1994304911 cites W2000389681 @default.
• W1994304911 cites W2009549527 @default.
• W1994304911 cites W2026996121 @default.
• W1994304911 cites W2027896336 @default.
• W1994304911 cites W2035502113 @default.
• W1994304911 cites W2043969800 @default.
• W1994304911 cites W2053593414 @default.
• W1994304911 cites W2054663479 @default.
• W1994304911 cites W2060640530 @default.
• W1994304911 cites W2068487526 @default.
• W1994304911 cites W2068756444 @default.
• W1994304911 cites W2080318130 @default.
• W1994304911 cites W2083425460 @default.
• W1994304911 cites W2084688676 @default.
• W1994304911 cites W2088216686 @default.
• W1994304911 cites W2096701477 @default.
• W1994304911 cites W2101649830 @default.
• W1994304911 cites W2105079657 @default.
• W1994304911 cites W2128775077 @default.
• W1994304911 cites W2136629589 @default.
• W1994304911 cites W2161607361 @default.
• W1994304911 cites W2169131207 @default.
• W1994304911 cites W2397434926 @default.
• W1994304911 cites W2409231129 @default.
• W1994304911 doi "https://doi.org/10.1182/blood-2007-08-105098" @default.
• W1994304911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2234783" @default.
• W1994304911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17848616" @default.
• W1994304911 hasPublicationYear "2007" @default.
• W1994304911 type Work @default.
• W1994304911 sameAs 1994304911 @default.
• W1994304911 citedByCount "105" @default.
• W1994304911 countsByYear W19943049112012 @default.
• W1994304911 countsByYear W19943049112013 @default.
• W1994304911 countsByYear W19943049112014 @default.
• W1994304911 countsByYear W19943049112015 @default.
• W1994304911 countsByYear W19943049112016 @default.
• W1994304911 countsByYear W19943049112017 @default.
• W1994304911 countsByYear W19943049112018 @default.
• W1994304911 countsByYear W19943049112019 @default.
• W1994304911 countsByYear W19943049112020 @default.
• W1994304911 countsByYear W19943049112021 @default.
• W1994304911 countsByYear W19943049112022 @default.
• W1994304911 countsByYear W19943049112023 @default.
• W1994304911 crossrefType "journal-article" @default.
• W1994304911 hasAuthorship W1994304911A5027879891 @default.
• W1994304911 hasAuthorship W1994304911A5030315782 @default.
• W1994304911 hasAuthorship W1994304911A5032758552 @default.
• W1994304911 hasAuthorship W1994304911A5040851400 @default.
• W1994304911 hasAuthorship W1994304911A5070445093 @default.
• W1994304911 hasAuthorship W1994304911A5075920531 @default.
• W1994304911 hasAuthorship W1994304911A5077478635 @default.
• W1994304911 hasAuthorship W1994304911A5086984176 @default.
• W1994304911 hasBestOaLocation W19943049112 @default.
• W1994304911 hasConcept C12554922 @default.
• W1994304911 hasConcept C126322002 @default.
• W1994304911 hasConcept C14086860 @default.
• W1994304911 hasConcept C155672457 @default.
• W1994304911 hasConcept C159654299 @default.
• W1994304911 hasConcept C159973064 @default.
• W1994304911 hasConcept C171250308 @default.
• W1994304911 hasConcept C185592680 @default.
• W1994304911 hasConcept C192562407 @default.
• W1994304911 hasConcept C203014093 @default.
• W1994304911 hasConcept C2777557582 @default.
• W1994304911 hasConcept C2778382381 @default.
• W1994304911 hasConcept C2780868878 @default.
• W1994304911 hasConcept C55493867 @default.
• W1994304911 hasConcept C71924100 @default.
• W1994304911 hasConcept C86181022 @default.
• W1994304911 hasConcept C86803240 @default.
• W1994304911 hasConceptScore W1994304911C12554922 @default.
• W1994304911 hasConceptScore W1994304911C126322002 @default.
• W1994304911 hasConceptScore W1994304911C14086860 @default.
• W1994304911 hasConceptScore W1994304911C155672457 @default.
• W1994304911 hasConceptScore W1994304911C159654299 @default.
• W1994304911 hasConceptScore W1994304911C159973064 @default.
• W1994304911 hasConceptScore W1994304911C171250308 @default.
• W1994304911 hasConceptScore W1994304911C185592680 @default.
• W1994304911 hasConceptScore W1994304911C192562407 @default.

• next