Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994308085> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1994308085 endingPage "1502" @default.
- W1994308085 startingPage "1497" @default.
- W1994308085 abstract "Pulsed field gel electrophoresis showed that caffeic acid induced DNA strand breaks in cultured human cells in the presence of Mn(II). With alkali treatment, DNA single-strand breaks were observed. The strand breakage was increased by the treatment of buthionine sulphoximine (a GSH synthesis inhibitor) and 3-aminotriazol (a catalase inhibitor) and decreased by catalase, indicating the involvement of H2O2. The DNA damage was decreased by o-phenanthroline, indicating the involvement of transition metal ion. Damage to isolated DNA from c-Ha-ras-1 protooncogene was investigated by a DNA sequencing technique. Caffeic acid caused DNA damage hi the presence of Cu(II) but not in the presence of either Mn(II) or Fe(III). Caffeic acid plus Cu(II) induced piperidine-labile sites frequently at thymine residues, especially of the 5′-GTC-3′ and 5′-CTG-3′ sequences. Typical OH scavengers showed no inhibitory effects. The inhibitory effects of bathocuproine and catalase on Cu(II)-mediated DNA damage suggest that Cu(I) and H2O2 have important roles in the production of active species causing DNA damage. The Cu(II)-mediated DNA damage was enhanced by pre-incubation of caffeic acid with Mn(II). Mn(II) or Cu(II)-catalyzed autoxidation of caffeic acid produced H2O2 with efficiency of Mn(II) > Cu(II). These results suggest that in the presence of Mn(II) or Cu(II), caffeic acid produces H2O2, which is activated by transition metals to cause damage to DNA in vitro and probably in cultured cells." @default.
- W1994308085 created "2016-06-24" @default.
- W1994308085 creator A5039674616 @default.
- W1994308085 creator A5039985741 @default.
- W1994308085 creator A5077773100 @default.
- W1994308085 creator A5079621606 @default.
- W1994308085 date "1992-01-01" @default.
- W1994308085 modified "2023-10-17" @default.
- W1994308085 title "Caffeic acid causes metal-dependent damage to cellular and isolated DNA through H<sub>2</sub>O<sub>2</sub> formation" @default.
- W1994308085 doi "https://doi.org/10.1093/carcin/13.9.1497" @default.
- W1994308085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1394830" @default.
- W1994308085 hasPublicationYear "1992" @default.
- W1994308085 type Work @default.
- W1994308085 sameAs 1994308085 @default.
- W1994308085 citedByCount "48" @default.
- W1994308085 countsByYear W19943080852013 @default.
- W1994308085 countsByYear W19943080852016 @default.
- W1994308085 countsByYear W19943080852023 @default.
- W1994308085 crossrefType "journal-article" @default.
- W1994308085 hasAuthorship W1994308085A5039674616 @default.
- W1994308085 hasAuthorship W1994308085A5039985741 @default.
- W1994308085 hasAuthorship W1994308085A5077773100 @default.
- W1994308085 hasAuthorship W1994308085A5079621606 @default.
- W1994308085 hasConcept C143425029 @default.
- W1994308085 hasConcept C153911025 @default.
- W1994308085 hasConcept C181199279 @default.
- W1994308085 hasConcept C185592680 @default.
- W1994308085 hasConcept C2778004101 @default.
- W1994308085 hasConcept C2778224086 @default.
- W1994308085 hasConcept C2778979269 @default.
- W1994308085 hasConcept C552990157 @default.
- W1994308085 hasConcept C55493867 @default.
- W1994308085 hasConcept C86803240 @default.
- W1994308085 hasConceptScore W1994308085C143425029 @default.
- W1994308085 hasConceptScore W1994308085C153911025 @default.
- W1994308085 hasConceptScore W1994308085C181199279 @default.
- W1994308085 hasConceptScore W1994308085C185592680 @default.
- W1994308085 hasConceptScore W1994308085C2778004101 @default.
- W1994308085 hasConceptScore W1994308085C2778224086 @default.
- W1994308085 hasConceptScore W1994308085C2778979269 @default.
- W1994308085 hasConceptScore W1994308085C552990157 @default.
- W1994308085 hasConceptScore W1994308085C55493867 @default.
- W1994308085 hasConceptScore W1994308085C86803240 @default.
- W1994308085 hasIssue "9" @default.
- W1994308085 hasLocation W19943080851 @default.
- W1994308085 hasLocation W19943080852 @default.
- W1994308085 hasOpenAccess W1994308085 @default.
- W1994308085 hasPrimaryLocation W19943080851 @default.
- W1994308085 hasRelatedWork W111527684 @default.
- W1994308085 hasRelatedWork W1964876920 @default.
- W1994308085 hasRelatedWork W2012563490 @default.
- W1994308085 hasRelatedWork W2025360090 @default.
- W1994308085 hasRelatedWork W2074200605 @default.
- W1994308085 hasRelatedWork W2126904341 @default.
- W1994308085 hasRelatedWork W2268862562 @default.
- W1994308085 hasRelatedWork W2354614562 @default.
- W1994308085 hasRelatedWork W2384589881 @default.
- W1994308085 hasRelatedWork W4310447761 @default.
- W1994308085 hasVolume "13" @default.
- W1994308085 isParatext "false" @default.
- W1994308085 isRetracted "false" @default.
- W1994308085 magId "1994308085" @default.
- W1994308085 workType "article" @default.