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- W1994313426 abstract "The amino-bisphosphonates are first-line therapy for the treatment of most patients with osteoporosis, with proven efficacy to reduce fracture risk at the spine, hip, and other nonvertebral skeletal sites. Further, bisphosphonates have been associated with a significant decrease in morbidity and increase in survival. Following the use of bisphosphonates in millions of patients in clinical practice, some unexpected possible adverse effects have been reported, including osteonecrosis of the jaw, atypical femur fractures, atrial fibrillation, and esophageal cancer. Because bisphosphonates are incorporated into the skeleton and continue to exert an antiresorptive effect for a period of time after dosing is discontinued, the concept of a drug holiday has emerged, whereby the risk of adverse effects might be decreased while the patient still benefits from antifracture efficacy. Patients receiving bisphosphonates who are not at high risk for fracture are potential candidates for a drug holiday, while for those with bone mineral density in the osteoporosis range or previous history of fragility fracture, the benefits of continuing therapy probably far outweigh the risk of harm." @default.
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- W1994313426 date "2013-01-01" @default.
- W1994313426 modified "2023-10-16" @default.
- W1994313426 title "Bisphosphonate Therapy for Osteoporosis: Benefits, Risks, and Drug Holiday" @default.
- W1994313426 cites W1491394012 @default.
- W1994313426 cites W1526826623 @default.
- W1994313426 cites W162186431 @default.
- W1994313426 cites W189554621 @default.
- W1994313426 cites W1964692065 @default.
- W1994313426 cites W1966953299 @default.
- W1994313426 cites W1966953695 @default.
- W1994313426 cites W1972185253 @default.
- W1994313426 cites W1973356978 @default.
- W1994313426 cites W1983427347 @default.
- W1994313426 cites W1984754135 @default.
- W1994313426 cites W1990119475 @default.
- W1994313426 cites W1990729029 @default.
- W1994313426 cites W1990771263 @default.
- W1994313426 cites W1993035292 @default.
- W1994313426 cites W2001013535 @default.
- W1994313426 cites W2003993002 @default.
- W1994313426 cites W2005141997 @default.
- W1994313426 cites W2005348923 @default.
- W1994313426 cites W2006021879 @default.
- W1994313426 cites W2011591829 @default.
- W1994313426 cites W2012608865 @default.
- W1994313426 cites W2015291798 @default.
- W1994313426 cites W2015489649 @default.
- W1994313426 cites W2019018649 @default.
- W1994313426 cites W2019292020 @default.
- W1994313426 cites W2022212934 @default.
- W1994313426 cites W2023000421 @default.
- W1994313426 cites W2023649596 @default.
- W1994313426 cites W2024143452 @default.
- W1994313426 cites W2024412436 @default.
- W1994313426 cites W2026123506 @default.
- W1994313426 cites W2026965697 @default.
- W1994313426 cites W2028195029 @default.
- W1994313426 cites W2030207344 @default.
- W1994313426 cites W2032829585 @default.
- W1994313426 cites W2038361874 @default.
- W1994313426 cites W2039963188 @default.
- W1994313426 cites W2041371036 @default.
- W1994313426 cites W2045947279 @default.
- W1994313426 cites W2047558199 @default.
- W1994313426 cites W2049602150 @default.
- W1994313426 cites W2057332307 @default.
- W1994313426 cites W2072396430 @default.
- W1994313426 cites W2076157012 @default.
- W1994313426 cites W2077941564 @default.
- W1994313426 cites W2084269679 @default.
- W1994313426 cites W2087929119 @default.
- W1994313426 cites W2091705733 @default.
- W1994313426 cites W2093082282 @default.
- W1994313426 cites W2094326312 @default.
- W1994313426 cites W2094638050 @default.
- W1994313426 cites W2099054178 @default.
- W1994313426 cites W2099244701 @default.
- W1994313426 cites W2102123887 @default.
- W1994313426 cites W2106406207 @default.
- W1994313426 cites W2106649747 @default.
- W1994313426 cites W2107494198 @default.
- W1994313426 cites W2118377751 @default.
- W1994313426 cites W2124527463 @default.
- W1994313426 cites W2134304734 @default.
- W1994313426 cites W2134339550 @default.
- W1994313426 cites W2135241080 @default.
- W1994313426 cites W2135327653 @default.
- W1994313426 cites W2136292511 @default.
- W1994313426 cites W2150904792 @default.
- W1994313426 cites W2151845115 @default.
- W1994313426 cites W2153009489 @default.
- W1994313426 cites W2155236480 @default.
- W1994313426 cites W2157362302 @default.
- W1994313426 cites W2157979607 @default.
- W1994313426 cites W2161837912 @default.
- W1994313426 cites W2163830908 @default.
- W1994313426 cites W2166970835 @default.
- W1994313426 cites W2167650352 @default.
- W1994313426 cites W2336517627 @default.
- W1994313426 cites W2624963411 @default.
- W1994313426 cites W4376595748 @default.
- W1994313426 doi "https://doi.org/10.1016/j.amjmed.2012.06.023" @default.
- W1994313426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23177553" @default.
- W1994313426 hasPublicationYear "2013" @default.
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