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- W1994327324 abstract "Introduction: Several types of D2R and D1R heteroreceptor complexes were discovered in the indirect and direct pathways of the striatum, respectively. The hypothesis is given that changes in the function of the dopamine heteroreceptor complexes may help us understand the molecular mechanisms underlying the motor complications of long-term therapy in Parkinson’s disease (PD) with l-DOPA and dopamine receptor agonists.Areas covered: In the indirect pathway, the potential role of the A2AR-D2R, A2AR-D2R-mGluR5 and D2R-NMDAR heteroreceptor complexes in PD are covered and in the direct pathway, the D1R-D3R, A1R-D1R, D1R-NMDAR and putative A1R-D1R-D3R heteroreceptor complexes.Expert opinion: One explanation for the more powerful ability of l-DOPA treatment versus treatment with the partial dopamine receptor agonist/antagonist activity to induce dyskinesias, may be that dopamine formed from l-DOPA acts as a full agonist. The field of D1R and D2R heteroreceptor complexes in the CNS opens up a new understanding of the wearing off of the antiparkinson actions of l-DOPA and dopamine receptor agonists and the production of l-DOPA-induced dyskinesias. It can involve a reorganization of the D1R and D2R heteroreceptor complexes and a disbalance of the D1R and D2R homomers versus non-dopamine receptor homomers in the direct and indirect pathways." @default.
- W1994327324 created "2016-06-24" @default.
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- W1994327324 creator A5078169923 @default.
- W1994327324 date "2014-12-08" @default.
- W1994327324 modified "2023-10-11" @default.
- W1994327324 title "Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease" @default.
- W1994327324 cites W1491097823 @default.
- W1994327324 cites W1533056363 @default.
- W1994327324 cites W1553758505 @default.
- W1994327324 cites W1558961132 @default.
- W1994327324 cites W1579201202 @default.
- W1994327324 cites W1636386427 @default.
- W1994327324 cites W1649187440 @default.
- W1994327324 cites W173323332 @default.
- W1994327324 cites W1964046843 @default.
- W1994327324 cites W1965565628 @default.
- W1994327324 cites W1967058690 @default.
- W1994327324 cites W1967736253 @default.
- W1994327324 cites W1968212856 @default.
- W1994327324 cites W1969801566 @default.
- W1994327324 cites W1971721543 @default.
- W1994327324 cites W1971999279 @default.
- W1994327324 cites W1973074412 @default.
- W1994327324 cites W1974740847 @default.
- W1994327324 cites W1975211606 @default.
- W1994327324 cites W1976145727 @default.
- W1994327324 cites W1976813386 @default.
- W1994327324 cites W1979769468 @default.
- W1994327324 cites W1980202815 @default.
- W1994327324 cites W1980620322 @default.
- W1994327324 cites W1981821582 @default.
- W1994327324 cites W1982939523 @default.
- W1994327324 cites W1986144006 @default.
- W1994327324 cites W1987188076 @default.
- W1994327324 cites W1987380827 @default.
- W1994327324 cites W1988856687 @default.
- W1994327324 cites W1989107065 @default.
- W1994327324 cites W1990068124 @default.
- W1994327324 cites W1990128139 @default.
- W1994327324 cites W1990269363 @default.
- W1994327324 cites W1991935832 @default.
- W1994327324 cites W1992872606 @default.
- W1994327324 cites W1993716787 @default.
- W1994327324 cites W1994675437 @default.
- W1994327324 cites W1994911797 @default.
- W1994327324 cites W1997586459 @default.
- W1994327324 cites W1999401390 @default.
- W1994327324 cites W2000699330 @default.
- W1994327324 cites W2000939164 @default.
- W1994327324 cites W2002287054 @default.
- W1994327324 cites W2004144625 @default.
- W1994327324 cites W2005673668 @default.
- W1994327324 cites W2006164302 @default.
- W1994327324 cites W2008063224 @default.
- W1994327324 cites W2014365582 @default.
- W1994327324 cites W2015594730 @default.
- W1994327324 cites W2016029553 @default.
- W1994327324 cites W2016124628 @default.
- W1994327324 cites W2018471307 @default.
- W1994327324 cites W2020174502 @default.
- W1994327324 cites W2020815389 @default.
- W1994327324 cites W2021574933 @default.
- W1994327324 cites W2022370123 @default.
- W1994327324 cites W2022966746 @default.
- W1994327324 cites W2023845267 @default.
- W1994327324 cites W2025417981 @default.
- W1994327324 cites W2026920991 @default.
- W1994327324 cites W2028656651 @default.
- W1994327324 cites W2030152049 @default.
- W1994327324 cites W2030301533 @default.
- W1994327324 cites W2030652795 @default.
- W1994327324 cites W2031326058 @default.
- W1994327324 cites W2032609908 @default.
- W1994327324 cites W2033092161 @default.
- W1994327324 cites W2033380212 @default.
- W1994327324 cites W2033662966 @default.
- W1994327324 cites W2035252993 @default.
- W1994327324 cites W2036212527 @default.
- W1994327324 cites W2036646509 @default.
- W1994327324 cites W2037673105 @default.
- W1994327324 cites W2038505488 @default.
- W1994327324 cites W2039164791 @default.
- W1994327324 cites W2039482493 @default.
- W1994327324 cites W2040315094 @default.
- W1994327324 cites W2040473339 @default.
- W1994327324 cites W2042326165 @default.
- W1994327324 cites W2043580671 @default.
- W1994327324 cites W2045367803 @default.
- W1994327324 cites W2045678127 @default.
- W1994327324 cites W2046425188 @default.
- W1994327324 cites W2046859444 @default.
- W1994327324 cites W2048051311 @default.
- W1994327324 cites W2052887259 @default.
- W1994327324 cites W2054769674 @default.
- W1994327324 cites W2055557007 @default.