FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994328156> ?p ?o ?g. }

• W1994328156 endingPage "S23" @default.
• W1994328156 startingPage "S23" @default.
• W1994328156 abstract "BackgroundThe incidence of endometrial cancer is increasing worldwide. Despite improved overall survival rates, its aetiopathogenesis remains complicated, although oestrogens are known causal factors. Among other factors thought to be implicated are the endocannabinoids. Anandamide (AEA), the prototypical endocannabinoid, has emerged as a possible factor in the pathogenesis of endometrial cancer because oestrogen regulates AEA concentrations and the expression of the cannabinoid receptors in other tissues. Furthermore, the endocannabinoid system is protective against the growth and spread of different malignancies. We aimed to investigate and quantify anandamide and its receptors in endometrial cancer.MethodsIn this single-centre study conducted at a UK teaching hospital, 31 patients with endometrial carcinomas (27 type 1, four type 2) and seven healthy age-matched controls with atrophic endometria were recruited. Biopsy samples were taken and divided into two—one for this study and the other for histological confirmation of diagnosis (graded according to the FIGO system). The biopsy sample for this study was further divided into two—one for AEA measurement and the other for quantitative RT-PCR. CB1 and CB2 transcript levels were measured in triplicate and normalised against the housekeeping genes PPIA, MRPL19, and IPO8. 15 of 31 cancer patients (12 type 1, three type 2) and all seven of the control group, volunteered blood for plasma collection. At hysterectomy, 31 endometrial cancer samples (27 type 1, four type 2) and seven age-matched atrophic control endometrial biopsy samples were obtained for tissue AEA measurement. Extracts from the plasma and endometrial homogenates were assessed for the presence of AEA with UHPLC-tandem mass spectrometry.FindingsIn the endometrial cancer tissues, both CB1 and CB2 transcript levels were significantly decreased by 90% (p<0·0004) and 80% (p< 0·0001), respectively, compared with atrophic tissues. Plasma AEA concentrations were significantly higher in patients with endometrial cancer than in the control group (mean 1·95 nM [SE 0·59] vs 1·06 [0·08], p=0·037). Plasma AEA concentrations in patients with type 1 disease were significantly higher than in control patients (2·17 [0·72] vs 1·06 [0·08], p<0·05), but in patients with type 2 disease there was no difference (1·08 [0·05]). Similarly, tissue AEA in patients with endometrial cancer was significantly higher than in the control group (5·45 nmol/g [SE 0·91] vs 1·77 [0·66], p=0·046). Tissue AEA was significantly higher in type 1 endometrial cancer than in atrophic samples (6·12 [0·98] vs 1·77 [0·66], p<0·05), but type 2 samples did not differ (0·90 [0·16]). Furthermore, in samples available for comparison (15 endometrial cancer, seven atrophic) there was a statistically significant correlation between plasma and tissue AEA concentrations (r=0·55, p=0·008).InterpretationThe results from this study suggest that downregulation of CB1 and CB2 receptor transcript levels and raised tissue and plasma AEA concentrations are linked in some way. We speculate that the endocannabinoid system is implicated in the aetiopathogenesis of endometrial cancer, but further work is warranted. The correlation between plasma and tissue AEA concentrations suggests that plasma AEA could be used as a biomarker for some forms of endometrial malignant disease, especially type 1 endometrioid adenocarcinoma. The endocannabinoid system thus presents an attractive novel target for pharmacological intervention in some endometrial malignancies.FundingUniversity Hospitals of Leicester NHS Trust." @default.
• W1994328156 created "2016-06-24" @default.
• W1994328156 creator A5012273658 @default.
• W1994328156 creator A5032148958 @default.
• W1994328156 creator A5035241425 @default.
• W1994328156 creator A5057151804 @default.
• W1994328156 creator A5075932505 @default.
• W1994328156 creator A5085139235 @default.
• W1994328156 creator A5090403370 @default.
• W1994328156 creator A5090515201 @default.
• W1994328156 date "2014-02-01" @default.
• W1994328156 modified "2023-10-16" @default.
• W1994328156 title "Association of cannabinoid receptor expression with anandamide concentrations in endometrial cancer" @default.
• W1994328156 doi "https://doi.org/10.1016/s0140-6736(14)60286-5" @default.
• W1994328156 hasPublicationYear "2014" @default.
• W1994328156 type Work @default.
• W1994328156 sameAs 1994328156 @default.
• W1994328156 citedByCount "6" @default.
• W1994328156 countsByYear W19943281562015 @default.
• W1994328156 countsByYear W19943281562016 @default.
• W1994328156 countsByYear W19943281562018 @default.
• W1994328156 countsByYear W19943281562020 @default.
• W1994328156 countsByYear W19943281562021 @default.
• W1994328156 countsByYear W19943281562022 @default.
• W1994328156 crossrefType "journal-article" @default.
• W1994328156 hasAuthorship W1994328156A5012273658 @default.
• W1994328156 hasAuthorship W1994328156A5032148958 @default.
• W1994328156 hasAuthorship W1994328156A5035241425 @default.
• W1994328156 hasAuthorship W1994328156A5057151804 @default.
• W1994328156 hasAuthorship W1994328156A5075932505 @default.
• W1994328156 hasAuthorship W1994328156A5085139235 @default.
• W1994328156 hasAuthorship W1994328156A5090403370 @default.
• W1994328156 hasAuthorship W1994328156A5090515201 @default.
• W1994328156 hasConcept C121608353 @default.
• W1994328156 hasConcept C126322002 @default.
• W1994328156 hasConcept C134018914 @default.
• W1994328156 hasConcept C142724271 @default.
• W1994328156 hasConcept C143998085 @default.
• W1994328156 hasConcept C148001335 @default.
• W1994328156 hasConcept C170493617 @default.
• W1994328156 hasConcept C2775934546 @default.
• W1994328156 hasConcept C2776606343 @default.
• W1994328156 hasConcept C2777088508 @default.
• W1994328156 hasConcept C2778938600 @default.
• W1994328156 hasConcept C2779522080 @default.
• W1994328156 hasConcept C2779742232 @default.
• W1994328156 hasConcept C2779783865 @default.
• W1994328156 hasConcept C2780871563 @default.
• W1994328156 hasConcept C2781197716 @default.
• W1994328156 hasConcept C46721173 @default.
• W1994328156 hasConcept C55493867 @default.
• W1994328156 hasConcept C71924100 @default.
• W1994328156 hasConcept C86803240 @default.
• W1994328156 hasConceptScore W1994328156C121608353 @default.
• W1994328156 hasConceptScore W1994328156C126322002 @default.
• W1994328156 hasConceptScore W1994328156C134018914 @default.
• W1994328156 hasConceptScore W1994328156C142724271 @default.
• W1994328156 hasConceptScore W1994328156C143998085 @default.
• W1994328156 hasConceptScore W1994328156C148001335 @default.
• W1994328156 hasConceptScore W1994328156C170493617 @default.
• W1994328156 hasConceptScore W1994328156C2775934546 @default.
• W1994328156 hasConceptScore W1994328156C2776606343 @default.
• W1994328156 hasConceptScore W1994328156C2777088508 @default.
• W1994328156 hasConceptScore W1994328156C2778938600 @default.
• W1994328156 hasConceptScore W1994328156C2779522080 @default.
• W1994328156 hasConceptScore W1994328156C2779742232 @default.
• W1994328156 hasConceptScore W1994328156C2779783865 @default.
• W1994328156 hasConceptScore W1994328156C2780871563 @default.
• W1994328156 hasConceptScore W1994328156C2781197716 @default.
• W1994328156 hasConceptScore W1994328156C46721173 @default.
• W1994328156 hasConceptScore W1994328156C55493867 @default.
• W1994328156 hasConceptScore W1994328156C71924100 @default.
• W1994328156 hasConceptScore W1994328156C86803240 @default.
• W1994328156 hasLocation W19943281561 @default.
• W1994328156 hasOpenAccess W1994328156 @default.
• W1994328156 hasPrimaryLocation W19943281561 @default.
• W1994328156 hasRelatedWork W1966549046 @default.
• W1994328156 hasRelatedWork W2015401786 @default.
• W1994328156 hasRelatedWork W2023948994 @default.
• W1994328156 hasRelatedWork W2036055518 @default.
• W1994328156 hasRelatedWork W2036248385 @default.
• W1994328156 hasRelatedWork W2067592086 @default.
• W1994328156 hasRelatedWork W2088083175 @default.
• W1994328156 hasRelatedWork W2787000414 @default.
• W1994328156 hasRelatedWork W2952377897 @default.
• W1994328156 hasRelatedWork W4297818596 @default.
• W1994328156 hasVolume "383" @default.
• W1994328156 isParatext "false" @default.
• W1994328156 isRetracted "false" @default.
• W1994328156 magId "1994328156" @default.
• W1994328156 workType "article" @default.