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• W1994333839 abstract "Despite continued appreciation of the potential role of vitamin D and omega-3 fatty acids in the prevention of cancer and cardiovascular disease (CVD), there remain no completed large-scale, randomized trials of these agents for the primary prevention of cancer or CVD in a population that has not been selected on the basis of elevated risk. The VITamin D and OmegA-3 TriaL (VITAL) is a 2 × 2 factorial randomized, double-blind, placebo-controlled trial of the benefits and risks of vitamin D (vitamin D3 [cholecalciferol], 2000 IU/d) and marine omega-3 fatty acids (Omacor® fish oil, a 1 g/d) in the primary prevention of cancer and CVD among 25,875 men and women, aged ≥50 and ≥55 years, respectively. Randomization began in November 2011 and was completed in March 2014. This report will describe the rationale for the trial and currently available randomized trial data, summarize related ongoing large-scale trials, and provide a brief overview of study design, and an update on randomization milestones, racial/ethnic diversity, biorepository activities, in-depth phenotyping of a subcohort, and ancillary studies." @default.
• W1994333839 created "2016-06-24" @default.
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• W1994333839 creator A5049411008 @default.
• W1994333839 date "2016-01-01" @default.
• W1994333839 modified "2023-10-17" @default.
• W1994333839 title "Update on the Vitamin D and OmegA-3 trial (VITAL)" @default.
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• W1994333839 doi "https://doi.org/10.1016/j.jsbmb.2015.04.006" @default.
• W1994333839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4600007" @default.
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