Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994334564> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1994334564 endingPage "1470" @default.
- W1994334564 startingPage "1461" @default.
- W1994334564 abstract "We have used a combined chemical-enzymatic approach to facilitate the total synthesis of the 20-residue peptaibol, alamethicin. The 1–11 segment of alamethicin, having a C-terminal Gly, and the 12–20 segment, having an N-terminal Leu, were prepared by well-established chemical methods, and then coupled using papain to afford a 54% yield of alamethicin in straightforward fashion. In contrast to the reported chemical syntheses of alamethicin requiring side-chain protection at Glu, 18 the papain-catalyzed coupling proceeded readily and selectively using a C-terminal segment having a free γ-carboxyl group at this position. Several alamethicin partial sequences were obtained via enzymatic formation of the Gly 11−Leu12 bond. The high efficiency of this route is illustrated by the enzymatic assembly of the 1–17 alamethicin fragment on a 400–mg scale in 62% yield. An alternative route to alamethicin through enzymatic formation of the Ala6−Gln7 bond was less successful because of a low yield in the final coupling. © 1992 John Wiley & Sons, Inc." @default.
- W1994334564 created "2016-06-24" @default.
- W1994334564 creator A5002271819 @default.
- W1994334564 creator A5003628824 @default.
- W1994334564 creator A5031752704 @default.
- W1994334564 creator A5052003735 @default.
- W1994334564 creator A5061213234 @default.
- W1994334564 creator A5071847487 @default.
- W1994334564 date "1992-11-01" @default.
- W1994334564 modified "2023-09-24" @default.
- W1994334564 title "Facilitated synthesis of peptaibols: Alamethicin via enzymatic segment condensation" @default.
- W1994334564 cites W1974924346 @default.
- W1994334564 cites W1980159883 @default.
- W1994334564 cites W2088977899 @default.
- W1994334564 cites W2949088762 @default.
- W1994334564 cites W3003363585 @default.
- W1994334564 cites W3005056887 @default.
- W1994334564 cites W3005315292 @default.
- W1994334564 doi "https://doi.org/10.1002/bip.360321106" @default.
- W1994334564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1457727" @default.
- W1994334564 hasPublicationYear "1992" @default.
- W1994334564 type Work @default.
- W1994334564 sameAs 1994334564 @default.
- W1994334564 citedByCount "17" @default.
- W1994334564 countsByYear W19943345642014 @default.
- W1994334564 countsByYear W19943345642016 @default.
- W1994334564 crossrefType "journal-article" @default.
- W1994334564 hasAuthorship W1994334564A5002271819 @default.
- W1994334564 hasAuthorship W1994334564A5003628824 @default.
- W1994334564 hasAuthorship W1994334564A5031752704 @default.
- W1994334564 hasAuthorship W1994334564A5052003735 @default.
- W1994334564 hasAuthorship W1994334564A5061213234 @default.
- W1994334564 hasAuthorship W1994334564A5071847487 @default.
- W1994334564 hasConcept C134121241 @default.
- W1994334564 hasConcept C178790620 @default.
- W1994334564 hasConcept C181199279 @default.
- W1994334564 hasConcept C185592680 @default.
- W1994334564 hasConcept C191897082 @default.
- W1994334564 hasConcept C192562407 @default.
- W1994334564 hasConcept C2779832904 @default.
- W1994334564 hasConcept C2780985075 @default.
- W1994334564 hasConcept C39944091 @default.
- W1994334564 hasConcept C41625074 @default.
- W1994334564 hasConcept C55493867 @default.
- W1994334564 hasConcept C71240020 @default.
- W1994334564 hasConceptScore W1994334564C134121241 @default.
- W1994334564 hasConceptScore W1994334564C178790620 @default.
- W1994334564 hasConceptScore W1994334564C181199279 @default.
- W1994334564 hasConceptScore W1994334564C185592680 @default.
- W1994334564 hasConceptScore W1994334564C191897082 @default.
- W1994334564 hasConceptScore W1994334564C192562407 @default.
- W1994334564 hasConceptScore W1994334564C2779832904 @default.
- W1994334564 hasConceptScore W1994334564C2780985075 @default.
- W1994334564 hasConceptScore W1994334564C39944091 @default.
- W1994334564 hasConceptScore W1994334564C41625074 @default.
- W1994334564 hasConceptScore W1994334564C55493867 @default.
- W1994334564 hasConceptScore W1994334564C71240020 @default.
- W1994334564 hasIssue "11" @default.
- W1994334564 hasLocation W19943345641 @default.
- W1994334564 hasLocation W19943345642 @default.
- W1994334564 hasOpenAccess W1994334564 @default.
- W1994334564 hasPrimaryLocation W19943345641 @default.
- W1994334564 hasRelatedWork W1986991025 @default.
- W1994334564 hasRelatedWork W2047888616 @default.
- W1994334564 hasRelatedWork W2062749443 @default.
- W1994334564 hasRelatedWork W2336956922 @default.
- W1994334564 hasRelatedWork W2401463829 @default.
- W1994334564 hasRelatedWork W2949184651 @default.
- W1994334564 hasRelatedWork W2950847194 @default.
- W1994334564 hasRelatedWork W2952271340 @default.
- W1994334564 hasRelatedWork W2952649848 @default.
- W1994334564 hasRelatedWork W4235951080 @default.
- W1994334564 hasVolume "32" @default.
- W1994334564 isParatext "false" @default.
- W1994334564 isRetracted "false" @default.
- W1994334564 magId "1994334564" @default.
- W1994334564 workType "article" @default.