FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994342017> ?p ?o ?g. }

• W1994342017 endingPage "379" @default.
• W1994342017 startingPage "373" @default.
• W1994342017 abstract "SUMMARY We studied the immunologic correlates of disease activity and differences among subgroups of patients with idiopathic inflammatory myopathy by analysing phenotypic and activation marker expression on peripheral blood mononuclear cells (PBMC). Compared with controls, myositis patients with clinically active disease (n = 51) had significantly lower proportions of CD8- cells and higher proportions of PBMC that expressed DR. CD3- DR, CD14- DR, interlcukin-2 receptors. and the late T cell activation markers CD26 and TLiSA1. TLiSA1 expression, a marker for cytotoxic differentiation, correlated significantly with both clinical activity indices and serum levels of muscle-associated enzymes. In serial studies of seven patients, the proportion of PBMC expressing MHC class II antigen and late T cell activation markers decreased as myositis disease activity decreased, independent of type of therapy. Among the clinical subgroups, polymyositis (n= 21) and inclusion body myositis (n=21) were virtually indistinguishable; dcrmatomyositis patients (n= 19) showed decreased proportions of CD3+DR+ and TLiSA1+ cells, and increased proportions of CD20+ and CD20+ DR+ cells compared with the other two groups. Patients with autoantibodies to histidyl-tRNA synthctasc (Jo-1 antigen. n= 11) had significantly lower proportions of CD3+ andCD4+ cells, lower CD4/CD8 ratios, and higher proportions of DR+ cells expressing CD20, compared with patients without anti-Jo-1 antibodies. These findings support the concept that activated lymphocytes, especially cells undergoing anamnestic responses and cytotoxic differentiation, are important in the pathogenesis of idiopathic myositis. Moreover, taken together with other studies, these data suggest that groups of patients segregated by clinical or autoantibody status have different mechanisms of systemic immune activation and immunopathology." @default.
• W1994342017 created "2016-06-24" @default.
• W1994342017 creator A5003891654 @default.
• W1994342017 creator A5033997225 @default.
• W1994342017 creator A5046727318 @default.
• W1994342017 creator A5056507445 @default.
• W1994342017 creator A5068826745 @default.
• W1994342017 date "1990-09-01" @default.
• W1994342017 modified "2023-10-17" @default.
• W1994342017 title "Lymphocyte activation markers in idiopathic myositis: changes with disease activity and differences among clinical and autoantibody subgroups" @default.
• W1994342017 cites W1496117711 @default.
• W1994342017 cites W1600164746 @default.
• W1994342017 cites W1601351723 @default.
• W1994342017 cites W1909461041 @default.
• W1994342017 cites W1966330632 @default.
• W1994342017 cites W1971971353 @default.
• W1994342017 cites W1975041769 @default.
• W1994342017 cites W1991486125 @default.
• W1994342017 cites W2007641665 @default.
• W1994342017 cites W2010176673 @default.
• W1994342017 cites W2027225741 @default.
• W1994342017 cites W2037760171 @default.
• W1994342017 cites W2046423041 @default.
• W1994342017 cites W2067166876 @default.
• W1994342017 cites W2071893438 @default.
• W1994342017 cites W2078827634 @default.
• W1994342017 cites W2092518825 @default.
• W1994342017 cites W2104068112 @default.
• W1994342017 cites W2123089812 @default.
• W1994342017 cites W2162995642 @default.
• W1994342017 cites W2314311014 @default.
• W1994342017 cites W2319014405 @default.
• W1994342017 cites W2329991082 @default.
• W1994342017 cites W2416282993 @default.
• W1994342017 cites W2432185953 @default.
• W1994342017 cites W70285711 @default.
• W1994342017 cites W87082738 @default.
• W1994342017 doi "https://doi.org/10.1111/j.1365-2249.1990.tb05341.x" @default.
• W1994342017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1534997" @default.
• W1994342017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2168821" @default.
• W1994342017 hasPublicationYear "1990" @default.
• W1994342017 type Work @default.
• W1994342017 sameAs 1994342017 @default.
• W1994342017 citedByCount "49" @default.
• W1994342017 countsByYear W19943420172012 @default.
• W1994342017 countsByYear W19943420172013 @default.
• W1994342017 countsByYear W19943420172014 @default.
• W1994342017 countsByYear W19943420172017 @default.
• W1994342017 countsByYear W19943420172019 @default.
• W1994342017 crossrefType "journal-article" @default.
• W1994342017 hasAuthorship W1994342017A5003891654 @default.
• W1994342017 hasAuthorship W1994342017A5033997225 @default.
• W1994342017 hasAuthorship W1994342017A5046727318 @default.
• W1994342017 hasAuthorship W1994342017A5056507445 @default.
• W1994342017 hasAuthorship W1994342017A5068826745 @default.
• W1994342017 hasBestOaLocation W19943420172 @default.
• W1994342017 hasConcept C114684123 @default.
• W1994342017 hasConcept C126322002 @default.
• W1994342017 hasConcept C137061746 @default.
• W1994342017 hasConcept C147483822 @default.
• W1994342017 hasConcept C159654299 @default.
• W1994342017 hasConcept C163764329 @default.
• W1994342017 hasConcept C167672396 @default.
• W1994342017 hasConcept C18031839 @default.
• W1994342017 hasConcept C202751555 @default.
• W1994342017 hasConcept C203014093 @default.
• W1994342017 hasConcept C2777327098 @default.
• W1994342017 hasConcept C2777761686 @default.
• W1994342017 hasConcept C2778751314 @default.
• W1994342017 hasConcept C2779387793 @default.
• W1994342017 hasConcept C2781232998 @default.
• W1994342017 hasConcept C55493867 @default.
• W1994342017 hasConcept C71924100 @default.
• W1994342017 hasConcept C86803240 @default.
• W1994342017 hasConceptScore W1994342017C114684123 @default.
• W1994342017 hasConceptScore W1994342017C126322002 @default.
• W1994342017 hasConceptScore W1994342017C137061746 @default.
• W1994342017 hasConceptScore W1994342017C147483822 @default.
• W1994342017 hasConceptScore W1994342017C159654299 @default.
• W1994342017 hasConceptScore W1994342017C163764329 @default.
• W1994342017 hasConceptScore W1994342017C167672396 @default.
• W1994342017 hasConceptScore W1994342017C18031839 @default.
• W1994342017 hasConceptScore W1994342017C202751555 @default.
• W1994342017 hasConceptScore W1994342017C203014093 @default.
• W1994342017 hasConceptScore W1994342017C2777327098 @default.
• W1994342017 hasConceptScore W1994342017C2777761686 @default.
• W1994342017 hasConceptScore W1994342017C2778751314 @default.
• W1994342017 hasConceptScore W1994342017C2779387793 @default.
• W1994342017 hasConceptScore W1994342017C2781232998 @default.
• W1994342017 hasConceptScore W1994342017C55493867 @default.
• W1994342017 hasConceptScore W1994342017C71924100 @default.
• W1994342017 hasConceptScore W1994342017C86803240 @default.
• W1994342017 hasIssue "3" @default.
• W1994342017 hasLocation W19943420171 @default.
• W1994342017 hasLocation W19943420172 @default.
• W1994342017 hasLocation W19943420173 @default.
• W1994342017 hasOpenAccess W1994342017 @default.
• W1994342017 hasPrimaryLocation W19943420171 @default.

• next