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- W1994356637 abstract "In cultured fibroblasts intoxicated with Clostridium difficile toxin B, a radioactive moiety was transferred from [14C-adenosine]NAD, but not from [14C-nicotinamide] NAD, into a cellular protein (MW 90,000). No labeling was detected in toxin-treated cultures not yet showing any toxin-induced cytopathogenic effect, whereas maximal labeling was obtained in cultures with about half of the cells showing a cytopathogenic effect. The radioactivity was removed from the substrate by treatment with snake venom phosphodiesterase. The results suggest that ADP-ribosylation of a cellular protein occurs in toxin B-treated cells and that this reaction may be responsible for development of the cytopathogenic effect." @default.
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- W1994356637 date "1986-08-01" @default.
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- W1994356637 title "ADP-ribosylation in cultured cells treated with Clostridiumdifficile toxin B" @default.
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- W1994356637 doi "https://doi.org/10.1016/s0006-291x(86)80080-8" @default.
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