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- W1994364558 abstract "Intra-tumoral hypoxia (low oxygen [O2] level) is an independent indicator of unfavorable patient diagnosis, and increasing evidence demonstrates that hypoxia contributes to a more aggressive tumor phenotype. Adaptation to hypoxia is predominantly regulated by two structurally related hypoxia inducible factors, HIF-1α and HIF-2α, which activate the expression of genes involved in proliferation, metabolism, angiogenesis, and metastasis. While highly homologous, HIF-1α and HIF-2α have been shown to have different roles in tumorigenesis dependent on specific tumor microenvironments. Here we summarize recent studies on HIF-2α and discuss the potential mechanisms whereby it contributes to tumor aggressiveness." @default.
- W1994364558 created "2016-06-24" @default.
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- W1994364558 date "2009-02-01" @default.
- W1994364558 modified "2023-10-17" @default.
- W1994364558 title "Hypoxia inducible factor-2α: a critical mediator of aggressive tumor phenotypes" @default.
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- W1994364558 doi "https://doi.org/10.1016/j.gde.2008.12.001" @default.
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