FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994366483> ?p ?o ?g. }

• W1994366483 endingPage "208" @default.
• W1994366483 startingPage "198" @default.
• W1994366483 abstract "The role(s) of protein kinases in the regulation of G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha was investigated in the osteoblast cell line MC3T3-E1. We have previously reported the stimulatory effects of tumor necrosis factor-alpha and A1F4-, an activator of G proteins, on this phospholipase pathway documented by a decrease in mass of PI and release of diacylglycerol. In this study, we further explored the mechanism(s) by which the tumor necrosis factor or A1F4(-)-promoted breakdown of phosphatidylinositol and the polyphosphoinositides by phospholipase C is regulated. Tumor necrosis factor-alpha was found to elicit a 4-5-fold increase in the formation of [3H]inositol-1,4-phosphate and [3H]inositol-1,4,5-phosphate; and a 36% increase in [3H]inositol-1-phosphate within 5 min in prelabeled cells. [3H]inositol-4-phosphate, a metabolite of [3H]inositol-1,4-phosphate and [3H]inositol-1,4,5-phosphate, was found to be the predominant phosphoinositol product of tumor necrosis factor-alpha and A1F4(-)-activated phospholipase C hydrolysis after 30 min. In addition, the preincubation of cells with pertussis toxin decreased the tumor necrosis factor-induced release of inositol phosphates by 53%. Inhibitors of protein kinase C, including Et-18-OMe and H-7, dramatically decreased the formation of [3H]inositol phosphates stimulated by either tumor necrosis factor-alpha or A1F4- by 90-100% but did not affect basal formation. The activation of cAMP-dependent protein kinase, or protein kinase A, by the treatment of cells with forskolin or 8-BrcAMP augmented basal, tumor necrosis factor-alpha and A1F4(-)-induced [3H]inositol phosphate formation. Therefore, we report that protein kinases can regulate tumor necrosis factor-alpha-initiated signalling at the cell surface in osteoblasts through effects on the coupling between receptor, G-protein and phosphatidylinositol-specific phospholipase C." @default.
• W1994366483 created "2016-06-24" @default.
• W1994366483 creator A5018346750 @default.
• W1994366483 creator A5063108298 @default.
• W1994366483 date "1997-05-01" @default.
• W1994366483 modified "2023-09-23" @default.
• W1994366483 title "Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts" @default.
• W1994366483 cites W1481451080 @default.
• W1994366483 cites W1494170055 @default.
• W1994366483 cites W1494647602 @default.
• W1994366483 cites W1499411585 @default.
• W1994366483 cites W1513905140 @default.
• W1994366483 cites W1521095349 @default.
• W1994366483 cites W1522007155 @default.
• W1994366483 cites W1543867248 @default.
• W1994366483 cites W1586296071 @default.
• W1994366483 cites W1594891632 @default.
• W1994366483 cites W1596204790 @default.
• W1994366483 cites W1617966995 @default.
• W1994366483 cites W1621683903 @default.
• W1994366483 cites W1751790428 @default.
• W1994366483 cites W1964585383 @default.
• W1994366483 cites W1967203165 @default.
• W1994366483 cites W1972338749 @default.
• W1994366483 cites W1972760976 @default.
• W1994366483 cites W1973454785 @default.
• W1994366483 cites W1987000956 @default.
• W1994366483 cites W1990663093 @default.
• W1994366483 cites W1990938161 @default.
• W1994366483 cites W1996626314 @default.
• W1994366483 cites W1996689279 @default.
• W1994366483 cites W2002209097 @default.
• W1994366483 cites W2002865337 @default.
• W1994366483 cites W2004556731 @default.
• W1994366483 cites W2007451263 @default.
• W1994366483 cites W2008180198 @default.
• W1994366483 cites W2012106969 @default.
• W1994366483 cites W2016951403 @default.
• W1994366483 cites W2017347652 @default.
• W1994366483 cites W2018155868 @default.
• W1994366483 cites W2031043501 @default.
• W1994366483 cites W2031504111 @default.
• W1994366483 cites W2033123803 @default.
• W1994366483 cites W2033395786 @default.
• W1994366483 cites W2033684442 @default.
• W1994366483 cites W2041848155 @default.
• W1994366483 cites W2047888347 @default.
• W1994366483 cites W2048325240 @default.
• W1994366483 cites W2052082098 @default.
• W1994366483 cites W2057123987 @default.
• W1994366483 cites W2062748780 @default.
• W1994366483 cites W2064173499 @default.
• W1994366483 cites W2078411762 @default.
• W1994366483 cites W2083116993 @default.
• W1994366483 cites W2083726090 @default.
• W1994366483 cites W2083735475 @default.
• W1994366483 cites W2085909636 @default.
• W1994366483 cites W2092621634 @default.
• W1994366483 cites W2094944495 @default.
• W1994366483 cites W2127145932 @default.
• W1994366483 cites W2131115069 @default.
• W1994366483 cites W2140769991 @default.
• W1994366483 cites W2142153444 @default.
• W1994366483 cites W2174322658 @default.
• W1994366483 cites W2174520807 @default.
• W1994366483 cites W2234097292 @default.
• W1994366483 cites W2395274642 @default.
• W1994366483 doi "https://doi.org/10.1002/(sici)1097-4644(199705)65:2<198::aid-jcb6>3.0.co;2-p" @default.
• W1994366483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9136078" @default.
• W1994366483 hasPublicationYear "1997" @default.
• W1994366483 type Work @default.
• W1994366483 sameAs 1994366483 @default.
• W1994366483 citedByCount "6" @default.
• W1994366483 countsByYear W19943664832012 @default.
• W1994366483 crossrefType "journal-article" @default.
• W1994366483 hasAuthorship W1994366483A5018346750 @default.
• W1994366483 hasAuthorship W1994366483A5063108298 @default.
• W1994366483 hasConcept C12927208 @default.
• W1994366483 hasConcept C134018914 @default.
• W1994366483 hasConcept C170493617 @default.
• W1994366483 hasConcept C17991360 @default.
• W1994366483 hasConcept C181199279 @default.
• W1994366483 hasConcept C184235292 @default.
• W1994366483 hasConcept C185592680 @default.
• W1994366483 hasConcept C195794163 @default.
• W1994366483 hasConcept C2777427919 @default.
• W1994366483 hasConcept C2778597717 @default.
• W1994366483 hasConcept C2780610907 @default.
• W1994366483 hasConcept C36020004 @default.
• W1994366483 hasConcept C55493867 @default.
• W1994366483 hasConcept C62478195 @default.
• W1994366483 hasConcept C86803240 @default.
• W1994366483 hasConceptScore W1994366483C12927208 @default.
• W1994366483 hasConceptScore W1994366483C134018914 @default.
• W1994366483 hasConceptScore W1994366483C170493617 @default.
• W1994366483 hasConceptScore W1994366483C17991360 @default.
• W1994366483 hasConceptScore W1994366483C181199279 @default.
• W1994366483 hasConceptScore W1994366483C184235292 @default.

• next