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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994367051> ?p ?o ?g. }

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• W1994367051 abstract "Although motilin was identified >40 years ago as a gastrointestinal hormone capable of stimulating gastric emptying, the relatively recent availability of molecular tools and focus on its neuronal activities are now clarifying mechanisms of action. In rodents, only motilin receptor pseudogenes are identified. In human stomach, facilitation of enteric cholinergic activity is identified as the main mechanism by which gastric emptying is increased; some motilin agonists act in a prolonged manner, contrasting with motilin itself and with studies using recombinant receptors. As such, assays using recombinant receptors seem poor predictors of in vivo activity. High-throughput screening enabled selective motilin agonists to be identified, which together with enhanced understanding into neuromuscular actions of motilin, promises to deliver rational treatments of disorders with delayed gastric emptying." @default.
• W1994367051 created "2016-06-24" @default.
• W1994367051 creator A5048726120 @default.
• W1994367051 date "2012-12-01" @default.
• W1994367051 modified "2023-09-27" @default.
• W1994367051 title "Motilin receptor neuropharmacology: revised understanding" @default.
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• W1994367051 doi "https://doi.org/10.1016/j.coph.2012.07.012" @default.
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