Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994367354> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1994367354 endingPage "37" @default.
- W1994367354 startingPage "33" @default.
- W1994367354 abstract "Background: Enprostil, a synthetic dehydroprostaglandin E2 structural analogue primarily developed for treatment of gastritis, has been shown also to lower serum cholesterol. Methods: We studied cholesterol metabolism in seven hypercholesterolemic subjects before, during, and after a low-dose enprostil (18 μg/day) treatment, measuring serum lipids, cholesterol absorption by an oral double-isotope method, fecal cholesterol elimination by the balance technique, and fecal fat. In addition, an oral fat load test with vitamin A was performed. Results: The drug treatment reduced serum concentrations of total and low-density lipoprotein (LDL) cholesterol by 8.2% and 7.9% (p < 0.05), respectively, and cholesterol absorption efficiency by 18% (p < 0.05), and increased fecal output of neutral sterols by 20% (p < 0.05), bile acids by 24% (NS), and cholesterol synthesis by 30% (p < 0.05). Postabsorptive concentrations of triglycerides and vitamin A in chylomicrons were reduced 3-4 h after the intake of the test meal. Fecal fat excretion was doubled during the enprostil treatment. Conclusions: Enprostil reduces serum cholesterol concentrations, apparently by inhibiting cholesterol absorption so that fecal cholesterol elimination is increased in association with a mild fat malabsorption. Enhanced intestinal motility may contribute to these changes, frequently causing abdominal fullness or mild pain without diarrhea." @default.
- W1994367354 created "2016-06-24" @default.
- W1994367354 creator A5033922901 @default.
- W1994367354 creator A5051729476 @default.
- W1994367354 date "1995-01-01" @default.
- W1994367354 modified "2023-10-16" @default.
- W1994367354 title "Enprostil Impairs Cholesterol and Fat Absorption" @default.
- W1994367354 cites W1426259424 @default.
- W1994367354 cites W1513549688 @default.
- W1994367354 cites W1538354042 @default.
- W1994367354 cites W1971545594 @default.
- W1994367354 cites W1983311734 @default.
- W1994367354 cites W1988077175 @default.
- W1994367354 cites W2002811749 @default.
- W1994367354 cites W2007205094 @default.
- W1994367354 cites W2020968694 @default.
- W1994367354 cites W2024575510 @default.
- W1994367354 cites W2038891504 @default.
- W1994367354 cites W2043958926 @default.
- W1994367354 cites W2044459357 @default.
- W1994367354 cites W2052230096 @default.
- W1994367354 cites W2058952939 @default.
- W1994367354 cites W2072811190 @default.
- W1994367354 cites W2074542812 @default.
- W1994367354 cites W2088074245 @default.
- W1994367354 cites W2100537048 @default.
- W1994367354 cites W2116404316 @default.
- W1994367354 cites W2146030284 @default.
- W1994367354 cites W2156066000 @default.
- W1994367354 cites W2162719733 @default.
- W1994367354 cites W2162899357 @default.
- W1994367354 cites W2185676712 @default.
- W1994367354 cites W2314766391 @default.
- W1994367354 cites W89075765 @default.
- W1994367354 doi "https://doi.org/10.3109/00365529509093232" @default.
- W1994367354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7701247" @default.
- W1994367354 hasPublicationYear "1995" @default.
- W1994367354 type Work @default.
- W1994367354 sameAs 1994367354 @default.
- W1994367354 citedByCount "1" @default.
- W1994367354 crossrefType "journal-article" @default.
- W1994367354 hasAuthorship W1994367354A5033922901 @default.
- W1994367354 hasAuthorship W1994367354A5051729476 @default.
- W1994367354 hasConcept C10146269 @default.
- W1994367354 hasConcept C11772777 @default.
- W1994367354 hasConcept C126322002 @default.
- W1994367354 hasConcept C134018914 @default.
- W1994367354 hasConcept C151730666 @default.
- W1994367354 hasConcept C185592680 @default.
- W1994367354 hasConcept C2776940978 @default.
- W1994367354 hasConcept C2778163477 @default.
- W1994367354 hasConcept C2780072125 @default.
- W1994367354 hasConcept C2780439177 @default.
- W1994367354 hasConcept C61716771 @default.
- W1994367354 hasConcept C71924100 @default.
- W1994367354 hasConcept C8243546 @default.
- W1994367354 hasConcept C86803240 @default.
- W1994367354 hasConceptScore W1994367354C10146269 @default.
- W1994367354 hasConceptScore W1994367354C11772777 @default.
- W1994367354 hasConceptScore W1994367354C126322002 @default.
- W1994367354 hasConceptScore W1994367354C134018914 @default.
- W1994367354 hasConceptScore W1994367354C151730666 @default.
- W1994367354 hasConceptScore W1994367354C185592680 @default.
- W1994367354 hasConceptScore W1994367354C2776940978 @default.
- W1994367354 hasConceptScore W1994367354C2778163477 @default.
- W1994367354 hasConceptScore W1994367354C2780072125 @default.
- W1994367354 hasConceptScore W1994367354C2780439177 @default.
- W1994367354 hasConceptScore W1994367354C61716771 @default.
- W1994367354 hasConceptScore W1994367354C71924100 @default.
- W1994367354 hasConceptScore W1994367354C8243546 @default.
- W1994367354 hasConceptScore W1994367354C86803240 @default.
- W1994367354 hasIssue "1" @default.
- W1994367354 hasLocation W19943673541 @default.
- W1994367354 hasLocation W19943673542 @default.
- W1994367354 hasOpenAccess W1994367354 @default.
- W1994367354 hasPrimaryLocation W19943673541 @default.
- W1994367354 hasRelatedWork W1965927317 @default.
- W1994367354 hasRelatedWork W1978634877 @default.
- W1994367354 hasRelatedWork W2021846613 @default.
- W1994367354 hasRelatedWork W2028993205 @default.
- W1994367354 hasRelatedWork W2035331946 @default.
- W1994367354 hasRelatedWork W2154101925 @default.
- W1994367354 hasRelatedWork W2157000830 @default.
- W1994367354 hasRelatedWork W2236600389 @default.
- W1994367354 hasRelatedWork W2605915675 @default.
- W1994367354 hasRelatedWork W4240148004 @default.
- W1994367354 hasVolume "30" @default.
- W1994367354 isParatext "false" @default.
- W1994367354 isRetracted "false" @default.
- W1994367354 magId "1994367354" @default.
- W1994367354 workType "article" @default.