Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994391606> ?p ?o ?g. }
- W1994391606 endingPage "23" @default.
- W1994391606 startingPage "1" @default.
- W1994391606 abstract "Growth cones are highly motile extensions of growing neuronal processes that have a well-characterized cytoskeleton, which is necessary for motility and directed growth. In culture, neurons have been observed to extend processes on a variety of substrates made of cell adhesion molecules (CAMs) or extracellular matrix molecules (ECM molecules). We have previously shown that retinal ganglion cell (RGC) growth cones exhibit characteristic morphologies dependent on the substrate on which they are grown (Payne et al., 1992: Cell Motil. Cytoskel. 21:65–73). Upon contact with a sharp border between two substrates, the growth cones display rapid changes in morphology (Burden-Gulley et al., 1995: J. Neurosci. 15:4370–4381) that may result from extensive restructuring of the cytoskeleton. In the present study, immunocytochemical methods were used to examine the distribution of three cytoskeletal elements in RGC growth cones growing on L1, N-cadherin, or laminin as well as on dishes coated with alternating lanes of these substrates. Distinct distribution patterns of f-actin, microtubules (MTs), and neurofilaments (NFs) were observed in growth cones growing on individual substrates. At border regions between two substrates, growth cones with extensive lamellipodial contact with the second substrate were observed to have f-actin and MT distribution patterns appropriate for the new substrate encountered. Contact via filopodia alone did not evoke this change. Redistribution of NFs was observed only after the majority of the growth cone had crossed onto the second substrate. These results suggest that actin and MTs, but probably not NFs, are directly influenced by CAMs and ECM molecules to produce changes in growth cone morphology. The distribution of two members of the protein tyrosine kinase family, pp60src and p59fyn, and phosphorylated tyrosine residues was also examined. No differences were observed in the distribution patterns of the kinases and phosphorylated tyrosine residues in growth cones on any of the substrate molecules tested. In addition, the distribution patterns were unchanged in growth cones that contacted and crossed borders between two substrates. These results suggest that redistribution of pp60src or p59fyn is not required to produce alterations in growth cone morphology induced by contact with L1, N-cadherin or laminin. © 1996 Wiley-Liss, Inc." @default.
- W1994391606 created "2016-06-24" @default.
- W1994391606 creator A5043407578 @default.
- W1994391606 creator A5062194249 @default.
- W1994391606 date "1996-01-01" @default.
- W1994391606 modified "2023-09-27" @default.
- W1994391606 title "L1, N-cadherin, and laminin induce distinct distribution patterns of cytoskeletal elements in growth cones" @default.
- W1994391606 cites W1500609492 @default.
- W1994391606 cites W1515547441 @default.
- W1994391606 cites W1528639851 @default.
- W1994391606 cites W1599233927 @default.
- W1994391606 cites W1601155059 @default.
- W1994391606 cites W1604240807 @default.
- W1994391606 cites W1821405535 @default.
- W1994391606 cites W1928800192 @default.
- W1994391606 cites W1963744588 @default.
- W1994391606 cites W1964128572 @default.
- W1994391606 cites W1964816241 @default.
- W1994391606 cites W1968344191 @default.
- W1994391606 cites W1969898516 @default.
- W1994391606 cites W1971846421 @default.
- W1994391606 cites W1971909261 @default.
- W1994391606 cites W1972009259 @default.
- W1994391606 cites W1972308707 @default.
- W1994391606 cites W1973018275 @default.
- W1994391606 cites W1973524445 @default.
- W1994391606 cites W1978136184 @default.
- W1994391606 cites W1981378231 @default.
- W1994391606 cites W1988651587 @default.
- W1994391606 cites W1992267627 @default.
- W1994391606 cites W1992433733 @default.
- W1994391606 cites W1999833864 @default.
- W1994391606 cites W2001700083 @default.
- W1994391606 cites W2011645131 @default.
- W1994391606 cites W2014961733 @default.
- W1994391606 cites W2015396843 @default.
- W1994391606 cites W2018499918 @default.
- W1994391606 cites W2018752391 @default.
- W1994391606 cites W2021947797 @default.
- W1994391606 cites W2023618495 @default.
- W1994391606 cites W2024259606 @default.
- W1994391606 cites W2029231027 @default.
- W1994391606 cites W2029642897 @default.
- W1994391606 cites W2033344414 @default.
- W1994391606 cites W2041362832 @default.
- W1994391606 cites W2041520211 @default.
- W1994391606 cites W2042522249 @default.
- W1994391606 cites W2047158283 @default.
- W1994391606 cites W2047478825 @default.
- W1994391606 cites W2050599523 @default.
- W1994391606 cites W2052086914 @default.
- W1994391606 cites W2053216099 @default.
- W1994391606 cites W2057864153 @default.
- W1994391606 cites W2063963676 @default.
- W1994391606 cites W2065228349 @default.
- W1994391606 cites W2066327803 @default.
- W1994391606 cites W2066665678 @default.
- W1994391606 cites W2073726089 @default.
- W1994391606 cites W2074214743 @default.
- W1994391606 cites W2082124668 @default.
- W1994391606 cites W2084906680 @default.
- W1994391606 cites W2102215341 @default.
- W1994391606 cites W2104715092 @default.
- W1994391606 cites W2116506759 @default.
- W1994391606 cites W2124223766 @default.
- W1994391606 cites W2124436876 @default.
- W1994391606 cites W2130854592 @default.
- W1994391606 cites W2131832714 @default.
- W1994391606 cites W2138559670 @default.
- W1994391606 cites W2140972604 @default.
- W1994391606 cites W2157356402 @default.
- W1994391606 cites W2170195475 @default.
- W1994391606 cites W2170262134 @default.
- W1994391606 cites W2171854519 @default.
- W1994391606 cites W2171960232 @default.
- W1994391606 cites W2313907974 @default.
- W1994391606 cites W2320552204 @default.
- W1994391606 cites W2323279882 @default.
- W1994391606 doi "https://doi.org/10.1002/(sici)1097-0169(1996)35:1<1::aid-cm1>3.0.co;2-f" @default.
- W1994391606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8874962" @default.
- W1994391606 hasPublicationYear "1996" @default.
- W1994391606 type Work @default.
- W1994391606 sameAs 1994391606 @default.
- W1994391606 citedByCount "31" @default.
- W1994391606 countsByYear W19943916062012 @default.
- W1994391606 countsByYear W19943916062018 @default.
- W1994391606 crossrefType "journal-article" @default.
- W1994391606 hasAuthorship W1994391606A5043407578 @default.
- W1994391606 hasAuthorship W1994391606A5062194249 @default.
- W1994391606 hasConcept C109185818 @default.
- W1994391606 hasConcept C125705527 @default.
- W1994391606 hasConcept C135903288 @default.
- W1994391606 hasConcept C142669718 @default.
- W1994391606 hasConcept C1491633281 @default.
- W1994391606 hasConcept C149402561 @default.
- W1994391606 hasConcept C189165786 @default.
- W1994391606 hasConcept C20418707 @default.
- W1994391606 hasConcept C2779530196 @default.