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- W1994392525 abstract "The major inflammatory disease of the central nervous system is multiple sclerosis (MS). It is often considered a 2-stage disease with an initial inflammatory attack on myelin involving the 2 hallmarks of adaptive immunity: antigen-specific T cells and antibodies directed to protein and lipid components of the myelin sheath (1). This concerted attack involving the adaptive immune system is followed by a “degenerative” course involving the myelin itself, the oligodendrocytes that produce it, and the underlying axons and their neuronal cell bodies themselves in the gray matter. All of this culminates in significant cerebral atrophy as MS progresses (2). Whether or not there is really such a sequential and bifurcated temporal course between “inflammation” in the white matter, followed by neurodegeneration in the gray matter, is actually an open question. In this issue of PNAS, Derfuss et al. (3) identify, via a multifaceted approach including proteomics, one of the first examples of a target recognized by both T cells and antibodies that is located in gray matter. The target is contactin-2, a homologue of transiently-expressed axonal glycoprotein-1 (TAG-1) expressed on axons and in the juxtaparanodal region of oligodendrocytes producing myelin to insulate these axons (4), and by neurons in gray matter (5, 6)." @default.
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- W1994392525 date "2009-05-19" @default.
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- W1994392525 title "The gray aspects of white matter disease in multiple sclerosis" @default.
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- W1994392525 doi "https://doi.org/10.1073/pnas.0903377106" @default.
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