Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994401414> ?p ?o ?g. }
- W1994401414 endingPage "2776" @default.
- W1994401414 startingPage "2768" @default.
- W1994401414 abstract "Evidence has emerged that the clinical benefit of tamoxifen is related to the functional status of the hepatic metabolizing enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6 is the key enzyme responsible for the generation of the potent tamoxifen metabolite, endoxifen. Multiple studies have examined the relationship of CYP2D6 status to breast cancer outcomes in tamoxifen-treated women; the majority of studies demonstrated that women with impaired CYP2D6 metabolism have lower endoxifen concentrations and a greater risk of breast cancer recurrence. As a result, practitioners must be aware that some of the most commonly prescribed medications coadministered with tamoxifen interfere with CYP2D6 function, thereby reducing endoxifen concentrations and potentially increasing the risk of breast cancer recurrence. After reviewing the published data regarding tamoxifen metabolism and the evidence relating CYP2D6 status to breast cancer outcomes in tamoxifen-treated patients, we are providing a guide for the use of medications that inhibit CYP2D6 in patients administered tamoxifen." @default.
- W1994401414 created "2016-06-24" @default.
- W1994401414 creator A5008665323 @default.
- W1994401414 creator A5008767553 @default.
- W1994401414 creator A5047808879 @default.
- W1994401414 creator A5051516231 @default.
- W1994401414 creator A5054911795 @default.
- W1994401414 creator A5056312367 @default.
- W1994401414 creator A5062965638 @default.
- W1994401414 creator A5066722006 @default.
- W1994401414 creator A5069943533 @default.
- W1994401414 creator A5083904553 @default.
- W1994401414 date "2010-06-01" @default.
- W1994401414 modified "2023-10-14" @default.
- W1994401414 title "Coprescription of Tamoxifen and Medications That Inhibit CYP2D6" @default.
- W1994401414 cites W1493745198 @default.
- W1994401414 cites W1493749035 @default.
- W1994401414 cites W1595502980 @default.
- W1994401414 cites W1631027698 @default.
- W1994401414 cites W1703321169 @default.
- W1994401414 cites W1961026612 @default.
- W1994401414 cites W1964945591 @default.
- W1994401414 cites W196795570 @default.
- W1994401414 cites W1970531647 @default.
- W1994401414 cites W1972083432 @default.
- W1994401414 cites W1975472851 @default.
- W1994401414 cites W1980461372 @default.
- W1994401414 cites W1981125500 @default.
- W1994401414 cites W1991118471 @default.
- W1994401414 cites W1991279188 @default.
- W1994401414 cites W1992320105 @default.
- W1994401414 cites W1992568187 @default.
- W1994401414 cites W1993858402 @default.
- W1994401414 cites W1994834031 @default.
- W1994401414 cites W2000966892 @default.
- W1994401414 cites W2003017820 @default.
- W1994401414 cites W2006610890 @default.
- W1994401414 cites W2007504551 @default.
- W1994401414 cites W2008570013 @default.
- W1994401414 cites W2010299225 @default.
- W1994401414 cites W2013470272 @default.
- W1994401414 cites W2015092588 @default.
- W1994401414 cites W2017210748 @default.
- W1994401414 cites W2023061643 @default.
- W1994401414 cites W2027686083 @default.
- W1994401414 cites W2027692702 @default.
- W1994401414 cites W2029995696 @default.
- W1994401414 cites W2031205523 @default.
- W1994401414 cites W2042702640 @default.
- W1994401414 cites W2042859803 @default.
- W1994401414 cites W2044308633 @default.
- W1994401414 cites W2045654730 @default.
- W1994401414 cites W2046275998 @default.
- W1994401414 cites W2047246104 @default.
- W1994401414 cites W2057098692 @default.
- W1994401414 cites W2063345843 @default.
- W1994401414 cites W2065975926 @default.
- W1994401414 cites W2067693646 @default.
- W1994401414 cites W2072912489 @default.
- W1994401414 cites W2076741971 @default.
- W1994401414 cites W2079507344 @default.
- W1994401414 cites W2080356278 @default.
- W1994401414 cites W2088585390 @default.
- W1994401414 cites W2092173951 @default.
- W1994401414 cites W2092892055 @default.
- W1994401414 cites W2093770528 @default.
- W1994401414 cites W2103933819 @default.
- W1994401414 cites W2109252993 @default.
- W1994401414 cites W2115581335 @default.
- W1994401414 cites W2120981370 @default.
- W1994401414 cites W2127660956 @default.
- W1994401414 cites W2130377362 @default.
- W1994401414 cites W2133675074 @default.
- W1994401414 cites W2136820997 @default.
- W1994401414 cites W2148096512 @default.
- W1994401414 cites W2148875560 @default.
- W1994401414 cites W2151430007 @default.
- W1994401414 cites W2154444846 @default.
- W1994401414 cites W2156422485 @default.
- W1994401414 cites W2156455256 @default.
- W1994401414 cites W2166969772 @default.
- W1994401414 cites W2167050490 @default.
- W1994401414 cites W2167690131 @default.
- W1994401414 cites W2167785958 @default.
- W1994401414 cites W2248039697 @default.
- W1994401414 cites W2319439699 @default.
- W1994401414 cites W4249835573 @default.
- W1994401414 cites W4256354773 @default.
- W1994401414 doi "https://doi.org/10.1200/jco.2009.23.8931" @default.
- W1994401414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881853" @default.
- W1994401414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20439629" @default.
- W1994401414 hasPublicationYear "2010" @default.
- W1994401414 type Work @default.
- W1994401414 sameAs 1994401414 @default.
- W1994401414 citedByCount "115" @default.
- W1994401414 countsByYear W19944014142012 @default.
- W1994401414 countsByYear W19944014142013 @default.
- W1994401414 countsByYear W19944014142014 @default.