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• W1994401612 abstract "Horse platelets prelabeled with [14C]arachidonate (AA) rapidly degrade [14C]phosphatidylinositol (PI) to [14C]1,2-diacylglycerol (DG) upon treatment with deoxycholate (DOC). This phospholipase-C (PLC) activity is specific for PI since other phospholipids or neutral lipids are not affected. Although exogenous Ca2+ is not required for activity, EGTA or EDTA abolishes PI degradation. Addition of Mg2+ (1 mM) and ATP (1 mM) results in phosphorylation of the DG and production of phosphatidic acid (PA). Higher concentrations of DOC inhibit DG-kinase. These observations, together with the fact that different platelet agonists induce a rapid degradation of PI and production of PA, indicate that PLC and DG-kinase activities are intimately linked. Incubation of platelets with dibutyryl cyclic-AMP, cyclic AMP-phosphodiesterase inhibitors and pyridoxal-5′-phosphate, which prevent platelet aggregation, inhibits the DOC-dependent conversion of PI to DG. The activity of PLC may play a central role in mediating platelet function and aggregation." @default.
• W1994401612 created "2016-06-24" @default.
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• W1994401612 date "1979-09-01" @default.
• W1994401612 modified "2023-10-16" @default.
• W1994401612 title "Phosphatidylinositol-specific phospholipase-C of platelets: Association with 1,2-diacylglycerol-kinase and inhibition by cyclic-AMP" @default.
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• W1994401612 doi "https://doi.org/10.1016/0006-291x(79)91594-8" @default.
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