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- W1994402078 abstract "Exercise pulmonary hypertension (PHT) can develop in patients with organic mitral regurgitation (OMR), even when resting pulmonary arterial pressure (PAP) is normal. However, systolic PAP is not always available during stress echocardiography. The purpose of this study was to identify resting echocardiographic predictors of exercise PHT in OMR. Resting and exercise transthoracic echocardiography including Doppler and tissue Doppler imaging (TDI) quantification were performed in 66 consecutive patients (61±15 years, 55% of male) with moderate to severe OMR. LV longitudinal and filling functions were quantified by peak and time-to-peak velocities (TP) using TDI for Ea- and Sa-wave. PAP was derived from transtricuspid pressure gradient and was available during exercise in 52 patients (79%). Systolic PAP significantly increased during exercise (from 31±10 to 54±17mmHg, p<0.01) and exercise PHT (exercise PAP ≥60mmHg) was observed in 24 patients (46%). Patients with exercise PHT were significantly older (69±11 vs. 59±15 yrs, p=0.004) and had higher resting PAP (36±9 vs. 27±7mmHg, p=0.0004), higher septal E/Ea ratio (16±6 vs. 13±4, p=0.03), slower TP-Sa (127±27 vs. 153±30ms, p=0.002) and TP-Ea (456±48 vs. 483±50ms, p=0.03) and lower septal Ea velocity (6.4±2 vs. 7.4±3cm/s, p=0.01). Exercise PAP was correlated with age (r=0.39, p=0.004), resting TP-Sa (r=0.42, p=0.002) and septal E/Ea ratio (r=0.28, p=0.04). On multivariate analysis, after adjustment for age, sex and septal E/Ea ratio, the independent predictors of exercise PHT were resting systolic PAP (Odds-ratio (OR) =1.25, 95%CI: 1.05-1.4, p=0.003) and TPSa (OR=1.04, 95%CI: 1.01-1.1, p=0.03). This study shows that resting impaired LV longitudinal function is associated with exercise PHT in patients with OMR. The presence of resting subclinical LV dysfunction could play an important role in PHT." @default.
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- W1994402078 date "2010-01-01" @default.
- W1994402078 modified "2023-09-24" @default.
- W1994402078 title "124 Does Resting Left Ventricular Longitudinal Function may predict Exercise Pulmonary Hypertension in Organic Mitral Regurgitation?" @default.
- W1994402078 doi "https://doi.org/10.1016/s1878-6480(10)70126-9" @default.
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