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- W1994403909 abstract "Objective: Omentum transposition surgery (OT) applied to various neurodegenerative disorders has produced clinically significant improvement, which may be due to omentally-derived factors. To evaluate the clinical effect of left hemisphere OT in a primary progressive aphasia (PPA) patient, 3 year follow-up data were analysed. Methods: Left hemisphere OT was performed on a 68-year-old male with PPA, characterized by moderate dementia and severe expressive aphasia with relatively preserved comprehension, object recognition and visual-spatial abilities. He was longitudinally assessed with cognitive, functional, behavioral and brain HMPAO SPECT measures pre-OT, at baseline and every 3–6 months for 34 months. Results: All measures improved above baseline for >20 months and persisted at or above baseline for 34 months. Cortical activity increased by a maximum of 21% underneath transposed omentum and in synaptically connected areas, and persisted in >50% of the cortex for at least 12 months. Subjectively, family members observed improved verbal and non-verbal communication. Conclusion: OT produced a sustained, beneficial treatment effect in PPA and warrants further clinical and basic research to identify explanatory factors." @default.
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- W1994403909 date "2009-09-01" @default.
- W1994403909 modified "2023-10-16" @default.
- W1994403909 title "Omental therapy for primary progressive aphasia with tau negative histopathology: 3 year study" @default.
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- W1994403909 doi "https://doi.org/10.1179/174313209x382511" @default.
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