FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994415969> ?p ?o ?g. }

• W1994415969 endingPage "307" @default.
• W1994415969 startingPage "297" @default.
• W1994415969 abstract "Growth hormone (GH) is expressed in the chicken bursa of Fabricius (BF), an organ that undergoes three distinct developmental stages: rapid growth (late embryogenesis until 6-8 weeks of age [w]), plateaued growth (between 10 and 15w), and involution (after 18-20w). The distribution and abundance of GH-immunoreactivity (GH-IR) and GH mRNA expression in stromal and non-stromal bursal cells during development, as well as the potential anti-apoptotic effect of GH in bursal cell survival were the focus of this study. GH mRNA expression was mainly in the epithelial layer and in epithelial buds at embryonic day (ED) 15; at 2w it was widely distributed within the follicle and in the interfollicular epithelium (IFE); at 10w it clearly diminished in the epithelium; whereas at 20w it occurred in only a few cortical cells and in the connective tissue. Parallel changes in the relative proportion of GH mRNA expression (12, 21, 13, 1%) and GH-IR (19, 18, 11, <3%) were observed at ED 15, 2w, 10w, and 20w, respectively. During embryogenesis, GH-IR co-localized considerably with IgM-IR, but scarcely with IgG-IR, whereas the opposite was observed after hatching. Significant differences in bursal cell death occurred during development, with 9.3% of cells being apoptotic at ED 15, 0.4% at 2w, 0.23% at 10w, and 21.1% at 20w. Addition of GH increased cultured cell survival by a mechanism that involved suppression (up to 41%) of caspase-3 activity. Results suggest that autocrine/paracrine actions of bursal GH are involved in the differentiation and proliferation of B lymphocytes and in BF growth and cell survival in embryonic and neonatal chicks, whereas diminished GH expression in adults may result in bursal involution." @default.
• W1994415969 created "2016-06-24" @default.
• W1994415969 creator A5014344338 @default.
• W1994415969 creator A5044943603 @default.
• W1994415969 creator A5070081072 @default.
• W1994415969 creator A5071552792 @default.
• W1994415969 creator A5076791772 @default.
• W1994415969 creator A5080912984 @default.
• W1994415969 date "2010-06-01" @default.
• W1994415969 modified "2023-09-25" @default.
• W1994415969 title "Growth hormone expression in stromal and non-stromal cells in the bursa of Fabricius during bursal development and involution: Causal relationships?" @default.
• W1994415969 cites W1486014609 @default.
• W1994415969 cites W1532855220 @default.
• W1994415969 cites W1610585913 @default.
• W1994415969 cites W1737187684 @default.
• W1994415969 cites W1942214720 @default.
• W1994415969 cites W1965463342 @default.
• W1994415969 cites W1968404281 @default.
• W1994415969 cites W1969997082 @default.
• W1994415969 cites W1970846510 @default.
• W1994415969 cites W1976041627 @default.
• W1994415969 cites W1978185061 @default.
• W1994415969 cites W1985543164 @default.
• W1994415969 cites W2004697450 @default.
• W1994415969 cites W2013511883 @default.
• W1994415969 cites W2015590653 @default.
• W1994415969 cites W2018954851 @default.
• W1994415969 cites W2020803551 @default.
• W1994415969 cites W2028613780 @default.
• W1994415969 cites W2029603562 @default.
• W1994415969 cites W2032949304 @default.
• W1994415969 cites W2035709407 @default.
• W1994415969 cites W2040988807 @default.
• W1994415969 cites W2044485781 @default.
• W1994415969 cites W2049696685 @default.
• W1994415969 cites W2052665441 @default.
• W1994415969 cites W2053326179 @default.
• W1994415969 cites W2054421713 @default.
• W1994415969 cites W2061630091 @default.
• W1994415969 cites W2064646902 @default.
• W1994415969 cites W2075675212 @default.
• W1994415969 cites W2080678211 @default.
• W1994415969 cites W2080932186 @default.
• W1994415969 cites W2080973238 @default.
• W1994415969 cites W2081989598 @default.
• W1994415969 cites W2084401256 @default.
• W1994415969 cites W2084768160 @default.
• W1994415969 cites W2086240590 @default.
• W1994415969 cites W2088209632 @default.
• W1994415969 cites W2090934637 @default.
• W1994415969 cites W2092185055 @default.
• W1994415969 cites W2093825456 @default.
• W1994415969 cites W2098014397 @default.
• W1994415969 cites W2109023863 @default.
• W1994415969 cites W2121198501 @default.
• W1994415969 cites W2125749590 @default.
• W1994415969 cites W2135542028 @default.
• W1994415969 cites W2138302361 @default.
• W1994415969 cites W2145407859 @default.
• W1994415969 cites W2156518533 @default.
• W1994415969 cites W2167628135 @default.
• W1994415969 cites W2415023236 @default.
• W1994415969 cites W4236910496 @default.
• W1994415969 cites W4237847584 @default.
• W1994415969 cites W4238161974 @default.
• W1994415969 cites W4253124490 @default.
• W1994415969 cites W4254828336 @default.
• W1994415969 cites W4313307134 @default.
• W1994415969 cites W4313310502 @default.
• W1994415969 cites W2067152433 @default.
• W1994415969 doi "https://doi.org/10.1016/j.ygcen.2010.03.019" @default.
• W1994415969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20347824" @default.
• W1994415969 hasPublicationYear "2010" @default.
• W1994415969 type Work @default.
• W1994415969 sameAs 1994415969 @default.
• W1994415969 citedByCount "23" @default.
• W1994415969 countsByYear W19944159692012 @default.
• W1994415969 countsByYear W19944159692013 @default.
• W1994415969 countsByYear W19944159692014 @default.
• W1994415969 countsByYear W19944159692015 @default.
• W1994415969 countsByYear W19944159692017 @default.
• W1994415969 countsByYear W19944159692019 @default.
• W1994415969 countsByYear W19944159692020 @default.
• W1994415969 countsByYear W19944159692022 @default.
• W1994415969 crossrefType "journal-article" @default.
• W1994415969 hasAuthorship W1994415969A5014344338 @default.
• W1994415969 hasAuthorship W1994415969A5044943603 @default.
• W1994415969 hasAuthorship W1994415969A5070081072 @default.
• W1994415969 hasAuthorship W1994415969A5071552792 @default.
• W1994415969 hasAuthorship W1994415969A5076791772 @default.
• W1994415969 hasAuthorship W1994415969A5080912984 @default.
• W1994415969 hasConcept C126322002 @default.
• W1994415969 hasConcept C128240485 @default.
• W1994415969 hasConcept C134018914 @default.
• W1994415969 hasConcept C16685009 @default.
• W1994415969 hasConcept C16930146 @default.
• W1994415969 hasConcept C169760540 @default.
• W1994415969 hasConcept C170493617 @default.

• next